Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 2/20 | 0.42 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.41 |
| ▸ | HRH2 | P25021 | 2/20 | 0.40 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17574694 | 0.94 | GBA1 (0.47) | GBA1PDCD1CD274HRH3HRH2 | |
| SCHEMBL19958437 | 0.94 | GBA1 (0.47) | GBA1PDCD1CD274HRH3HRH2 | |
| SCHEMBL26012973 | 0.94 | GBA1 (0.47) | GBA1PDCD1CD274HRH3HRH2 | |
| SCHEMBL13519663 | 0.86 | KCNA3 (0.43) | GBA1PDCD1CD274HRH3HRH2 | |
| SCHEMBL18233564 | 0.86 | KCNA3 (0.43) | GBA1PDCD1CD274HRH3HRH2 | |
| SCHEMBL8085779 | 0.86 | KCNA3 (0.43) | GBA1PDCD1CD274HRH3HRH2 | |
| SCHEMBL11932479 | 0.85 | GBA1 (0.49) | GBA1HRH3HRH2HRH1SIGMAR1 | |
| SCHEMBL7375999 | 0.84 | HTR1A (0.49) | GBA1PDCD1CD274HRH3HRH2 | |
| SCHEMBL28960041 | 0.82 | PDCD1 (0.49) | PDCD1CD274HRH3HRH2HRH1 | |
| SCHEMBL9322512 | 0.82 | HRH3 (0.40) | GBA1PDCD1CD274HRH3HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3519393-B1 | SUBSTITUTED FUSED BI- OR TRI- HETEROCYCLIC COMPOUNDS AS EHMT2 INHIBITORS | EPIZYME INC (US) | 2022-05-18 | — | — | EP | disclosed |