Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.48 |
| ▸ | RIPK1 | Q13546 | 5/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27295996 | 0.70 | HDAC6 (0.52) | HDAC6RIPK1HDAC3ALDH1A1HPGD | |
| SCHEMBL5452480 | 0.69 | HDAC6 (0.50) | HDAC6HDAC1HDAC3HDAC2HDAC10 | |
| SCHEMBL5447769 | 0.68 | HDAC6 (0.50) | HDAC6HDAC1HDAC3HDAC2HDAC10 | |
| SCHEMBL5451508 | 0.67 | HDAC6 (0.47) | HDAC6HDAC1HDAC3HDAC2HDAC10 | |
| SCHEMBL5454441 | 0.66 | HDAC6 (0.46) | HDAC6HDAC1HDAC3HDAC2HDAC10 | |
| SCHEMBL5453454 | 0.66 | SMN1; SMN2 (0.48) | HDAC6HDAC1HDAC3HDAC2HDAC10 | |
| SCHEMBL5458916 | 0.66 | HDAC6 (0.46) | HDAC6HDAC1HDAC3HDAC2HDAC10 | |
| SCHEMBL5453519 | 0.65 | MEN1 (0.54) | HDAC6HDAC1HDAC3HDAC2HDAC10 | |
| SCHEMBL5448449 | 0.65 | THRB (0.48) | HDAC6HDAC1HDAC3HDAC2HDAC10 | |
| SCHEMBL20524111 | 0.65 | HDAC6 (1.00) | HDAC6HDAC1HDAC3HDAC2HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12024493-B2 | Isoxazole hydroxamic acids as histone deacetylase 6 inhibitors | THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) | 2024-07-02 | — | — | US | disclosed |
| US-20220153709-A1 | ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS | THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) | 2022-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220153709-A1 | ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS | HDAC1, HDAC7, HDAC5 | HDAC6 10/4885RIPK1 3859/4885HDAC1 1/4885 |
| US-12024493-B2 | Isoxazole hydroxamic acids as histone deacetylase 6 inhibitors | HDAC1, HDAC7, HDAC5 | HDAC6 10/4885RIPK1 3859/4885HDAC1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.