SCHEMBL24433422

SCHEMBL24433422

O=C(Nc1nccs1)C1CC12CCN(C(=O)OC(C(F)(F)F)C(F)(F)F)CC2

nearest known ligand 0.53

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 18/20 0.53
PLA2G7 Q13093 1/20 0.42
ABHD6 Q9BV23 1/20 0.42
FAAH O00519 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29656605 1.00 MGLL (0.53) MGLLPLA2G7ABHD6FAAH
SCHEMBL29779839 1.00 MGLL (0.53) MGLLPLA2G7ABHD6FAAH
SCHEMBL29656542 1.00 MGLL (0.53) MGLLPLA2G7ABHD6FAAH
SCHEMBL29656873 0.82 MGLL (0.46) MGLLPLA2G7ABHD6
SCHEMBL24433513 0.82 MGLL (0.46) MGLLPLA2G7ABHD6
SCHEMBL29657031 0.82 MGLL (0.46) MGLLPLA2G7ABHD6
SCHEMBL29656919 0.82 MGLL (0.46) MGLLPLA2G7ABHD6
SCHEMBL24433533 0.81 MGLL (0.46) MGLLPLA2G7ABHD6
SCHEMBL24433398 0.81 MGLL (0.51) MGLLPLA2G7ABHD6FAAH
SCHEMBL24433456 0.81 MGLL (0.50) MGLLFAAH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240018120-A1 MAGL INHIBITORS H. LUNDBECK A/S (DK) 2024-01-18 US disclosed
US-20240018120-A1 MAGL INHIBITORS H. LUNDBECK A/S (DK) 2024-01-18 US disclosed
US-20240018120-A1 MAGL INHIBITORS H. LUNDBECK A/S (DK) 2024-01-18 US disclosed
US-20220153721-A1 MAGL INHIBITORS H. LUNDBECK A/S (DK) 2022-05-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240018120-A1 MAGL INHIBITORS MAG, MAGI3, MAGT1 MGLL 5/4885PLA2G7 508/4885ABHD6 91/4885
US-20220153721-A1 MAGL INHIBITORS MAG, MAGI3, MAGT1 MGLL 5/4885PLA2G7 508/4885ABHD6 91/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.