Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 17/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 9/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.43 |
| ▸ | CDK1 | P06493 | 2/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | PAK4 | O96013 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | PRKCG | P05129 | 1/20 | 0.43 |
| ▸ | INSR | P06213 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24435821 | 0.84 | ERN1 (0.52) | ERN1MAPK10 | |
| SCHEMBL29633607 | 0.84 | ERN1 (0.52) | ERN1MAPK10 | |
| SCHEMBL24435785 | 0.84 | ERN1 (0.52) | ERN1MAPK10 | |
| SCHEMBL24435930 | 0.77 | ERN1 (0.54) | ERN1MAPK10 | |
| SCHEMBL29633594 | 0.77 | ERN1 (0.54) | ERN1MAPK10 | |
| SCHEMBL24435789 | 0.76 | ERN1 (0.53) | ERN1MAPK10 | |
| SCHEMBL21908758 | 0.70 | ERN1 (0.77) | ERN1MAPK10 | |
| SCHEMBL28551326 | 0.70 | ERN1 (0.77) | ERN1MAPK10 | |
| SCHEMBL25071816 | 0.70 | ERN1 (0.77) | ERN1MAPK10 | |
| SCHEMBL31011661 | 0.69 | ERN1 (0.56) | ERN1MAPK10CCNB2CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220153723-A1 | IRE1ALPHA INHIBITORS AND USES THEREOF | UNIVERSITY OF WASHINGTON | 2022-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220153723-A1 | IRE1ALPHA INHIBITORS AND USES THEREOF | XBP1, ERN2, ERN1 | ERN1 3/4885MAPK10 1017/4885CCNB2 4632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.