Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2447904 | 0.81 | CA12 (0.45) | MAPTSMN1; SMN2NPC1NFKB1RAB9A | |
| SCHEMBL7433658 | 0.79 | MAPT (0.59) | MAPTSMN1; SMN2NPC1NFKB1RAB9A | |
| SCHEMBL2462874 | 0.75 | KMT2A (0.51) | MAPTSMN1; SMN2NPSR1LMNAALDH1A1 | |
| SCHEMBL22291222 | 0.74 | NPC1 (0.54) | MAPTSMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL6297373 | 0.71 | MAPT (0.74) | MAPTSMN1; SMN2NPC1NFKB1RAB9A | |
| SCHEMBL3961650 | 0.70 | APP (0.59) | MAPTSMN1; SMN2NPC1RAB9ANPSR1 | |
| SCHEMBL18272220 | 0.69 | IDO1 (0.53) | MAPTSMN1; SMN2NPC1RAB9ANPSR1 | |
| SCHEMBL3629871 | 0.68 | NPC1 (0.59) | MAPTSMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL9947562 | 0.68 | MAPT (0.54) | MAPTSMN1; SMN2NPC1NFKB1RAB9A | |
| SCHEMBL2944913 | 0.68 | CA12 (0.62) | MAPTSMN1; SMN2RAB9ANPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8017782-B2 | hypogonadism and male infertility; ovulation induction | N.V. ORGANON (NL) | 2011-09-13 | — | — | US | disclosed |
| CN-101212971-B | 4-phenyl-5-0x0-l,4,5,6,7,8-hexahydr0quin0line derivatives as medicaments for the treatment of infertility | ORGANON NV | 2010-12-08 | — | — | CN | disclosed |
| US-20080262033-A1 | 4-Phenyl-5-Oxo-1,4,5,6,7,8- Hexahydroquinoline Derivatives as Medicaments for the Treatment of Infertility | MERCK SHARP & DOHME B.V. (NL) | 2008-10-23 | — | — | US | disclosed |
| EP-1879581-B1 | 4-PHENYL-5-0X0-l,4,5,6,7,8-HEXAHYDR0QËIN0LINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY | ORGANON NV (NL) | 2008-09-03 | — | — | EP | disclosed |
| CN-101212971-A | 4-phenyl-5-0x0-l,4,5,6,7,8-hexahydr0quin0line derivatives as medicaments for the treatment of infertility | ORGANON NV (NL) | 2008-07-02 | — | — | CN | disclosed |
| EP-1879581-A1 | 4-PHENYL-5-0X0-l,4,5,6,7,8-HEXAHYDR0QËIN0LINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY | N.V. Organon (NL) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006117371-A1 | 4-PHENYL-5-0X0-l,4,5,6,7,8-HEXAHYDR0QËIN0LINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY | N.V. ORGANON (NL) | 2006-11-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080262033-A1 | 4-Phenyl-5-Oxo-1,4,5,6,7,8- Hexahydroquinoline Derivatives as Medicaments for the Treatment of Infertility | KCNQ5, SRD5A1, KCNQ1 | MAPT 4204/4885SMN1; SMN2 3805/4885NPC1 1247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.