Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.59 |
| ▸ | RELA | Q04206 | 1/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.56 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6297373 | 0.86 | MAPT (0.74) | MAPTSMN1; SMN2NPC1NFKB1RAB9A | |
| SCHEMBL11337993 | 0.81 | ALDH1A1 (0.77) | MAPTSMN1; SMN2NPC1NFKB1RAB9A | |
| SCHEMBL27608521 | 0.81 | ALDH1A1 (0.58) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL2879297 | 0.80 | ALDH1A1 (0.57) | MAPTSMN1; SMN2NPSR1ALDH1A1HTR1A | |
| SCHEMBL17131798 | 0.80 | HTR1A (0.53) | MAPTSMN1; SMN2NPSR1ALDH1A1LMNA | |
| SCHEMBL26936544 | 0.80 | PTGS2 (0.59) | MAPTSMN1; SMN2PTGS2ALDH1A1LMNA | |
| SCHEMBL2443663 | 0.79 | MAPT (0.43) | MAPTSMN1; SMN2NPC1NFKB1RAB9A | |
| SCHEMBL2650257 | 0.78 | ALDH1A1 (0.59) | MAPTALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL21071296 | 0.78 | HTR1A (0.55) | MAPTSMN1; SMN2ALDH1A1LMNAHTR1A | |
| SCHEMBL6444060 | 0.78 | PDCD1 (0.56) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5321135-A | Process for the preparation of polycyclic compounds using ferric perchlorate and acid trifluoroacidic | TSUMURA & CO. (JP) | 1994-06-14 | — | — | US | disclosed |
| EP-0594890-A1 | Polycyclic compounds, their preparation and their use as phosphodiesterases inhibitors | TSUMURA & CO. (JP) | 1994-05-04 | — | — | EP | disclosed |
| EP-0511666-A1 | Process for the preparation of polycyclic compounds | TSUMURA & CO. (JP) | 1992-11-04 | — | — | EP | disclosed |