Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | PRKACA | P17612 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.31 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.31 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.31 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22490641 | 0.79 | EGLN2 (0.35) | CHEK1MAP4K4CSF1RPRKACAKDR | |
| SCHEMBL28873689 | 0.76 | NPC1 (0.35) | CHEK1MAP4K4CSF1RPRKACAKDR | |
| SCHEMBL30318567 | 0.76 | IDO1 (0.31) | CHEK1MAP4K4CSF1RPRKACAKDR | |
| SCHEMBL21438499 | 0.72 | RECQL (0.39) | EGLN2 | |
| SCHEMBL1907671 | 0.72 | PDE10A (0.34) | — | |
| SCHEMBL21439276 | 0.71 | TPMT (0.39) | EGLN2 | |
| SCHEMBL29115013 | 0.68 | EGLN2 (0.33) | CHEK1MAP4K4CSF1RPRKACAKDR | |
| SCHEMBL260187 | 0.67 | CDK8 (0.53) | CHEK1MAP4K4CSF1RPRKACAKDR | |
| SCHEMBL3231277 | 0.67 | CHEK1 (0.38) | CHEK1MAP4K4CSF1RPRKACAKDR | |
| SCHEMBL2571208 | 0.67 | PDE10A (0.32) | CHEK1MAP4K4CSF1RPRKACAKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022104079-A1 | PYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS BTK INHIBITORS | BIOGEN MA INC. (US) | 2022-05-19 | — | — | WO | disclosed |