Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 6/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PLCG2 | P16885 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17801236 | 0.84 | CHEK1 (0.47) | CHEK1BTKJAK2JAK1TYK2 | |
| SCHEMBL25236672 | 0.77 | CHEK1 (0.39) | CHEK1BTKJAK2JAK1TYK2 | |
| SCHEMBL30760486 | 0.76 | CHEK1 (0.43) | CHEK1BTKJAK2JAK1TYK2 | |
| SCHEMBL24437853 | 0.76 | RET (0.41) | CHEK1BTKJAK2JAK1TYK2 | |
| SCHEMBL24437850 | 0.75 | RET (0.40) | BTKCYP2C9PLCG2NFKB1NFKB2 | |
| SCHEMBL27170226 | 0.75 | BTK (0.56) | BTKFGFR2FGFR3FGFR1PIK3CD | |
| SCHEMBL24438004 | 0.75 | BTK (0.56) | BTKFGFR2FGFR3FGFR1PIK3CD | |
| SCHEMBL24437611 | 0.74 | BTK (0.56) | BTKJAK2JAK1TYK2JAK3 | |
| SCHEMBL21033225 | 0.72 | CHEK1 (0.50) | CHEK1JAK2JAK1TYK2JAK3 | |
| SCHEMBL21872222 | 0.72 | CHEK1 (0.39) | CHEK1BTKJAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022104079-A1 | PYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS BTK INHIBITORS | BIOGEN MA INC. (US) | 2022-05-19 | — | — | WO | disclosed |