Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 6/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 7/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PLCG2 | P16885 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24439168 | 0.81 | JAK2 (0.47) | BTKRETJAK1JAK3JAK2 | |
| SCHEMBL24438659 | 0.80 | PIK3CD (0.40) | BTKRETJAK1JAK3JAK2 | |
| SCHEMBL31201718 | 0.80 | MAPT (0.38) | BTKRETJAK1JAK3JAK2 | |
| SCHEMBL16427000 | 0.77 | POLB (0.39) | — | |
| SCHEMBL1901010 | 0.77 | ERN1 (0.48) | RET | |
| SCHEMBL24438940 | 0.76 | CHEK1 (0.42) | CHEK1BTKIRAK4JAK1JAK3 | |
| Formic Acid SCHEMBL31201799 | 0.73 | RET (0.44) | BTKRETPIM1PIM2 | |
| SCHEMBL30760263 | 0.73 | CHEK1 (0.45) | CHEK1BTKRETJAK1JAK3 | |
| SCHEMBL24437611 | 0.70 | BTK (0.56) | BTKJAK1JAK3JAK2TYK2 | |
| SCHEMBL19253538 | 0.67 | JAK2 (0.47) | CHEK1RETJAK1JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023247595-A1 | PYRAZOLOPYRAZINE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-12-28 | — | — | WO | disclosed |