Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | LTA4H | P09960 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23987189 | 0.87 | CYP1A2 (0.35) | NPC1RAB9ASMN1; SMN2KDM4ECYP3A4 | |
| SCHEMBL23978603 | 0.84 | PLK1 (0.36) | NPC1RAB9ASMN1; SMN2KDM4ECYP3A4 | |
| SCHEMBL22965748 | 0.83 | HTR1B (0.37) | NPC1RAB9AL3MBTL1KDM4ECYP3A4 | |
| SCHEMBL12186 | 0.80 | CYP1A2 (0.44) | NPC1RAB9ASMN1; SMN2TDP1KDM4E | |
| SCHEMBL91331 | 0.79 | CYP1A2 (0.44) | NPC1RAB9ASMN1; SMN2TDP1KDM4E | |
| SCHEMBL25455392 | 0.77 | PLG (0.31) | ALDH1A1 | |
| SCHEMBL8227728 | 0.76 | CNR1 (0.39) | NPC1RAB9ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL31125665 | 0.75 | CA12 (0.43) | — | |
| SCHEMBL28590491 | 0.75 | CA12 (0.43) | — | |
| SCHEMBL13547932 | 0.75 | ESR1 (0.37) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024044649-A2 | GTPase INHIBITORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2024-02-29 | — | — | WO | disclosed |
| US-20230346943-A1 | SPACER-MEDIATED CONTROL OF UNCAGING PHOTOCAGED MOLECULES | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2023-11-02 | — | — | US | disclosed |
| US-20230203003-A1 | Notch Inhibitors and Uses Thereof | STEMSYNERGY THERAPEUTICS, INC. | 2023-06-29 | — | — | US | disclosed |
| WO-2022109495-A1 | METHODS AND COMPOSITIONS FOR LINKING RNA STEM LOOPS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-05-27 | — | — | WO | disclosed |
| WO-2022104151-A1 | IRE1ALPHA INHIBITORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-05-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230203003-A1 | Notch Inhibitors and Uses Thereof | NOTCH1, NOTCH2, NOTCH4 | NPC1 1160/4885RAB9A 1874/4885SMN1; SMN2 4659/4885 |
| US-20230346943-A1 | SPACER-MEDIATED CONTROL OF UNCAGING PHOTOCAGED MOLECULES | DCLRE1A, PCNA, HMBS | NPC1 3154/4885RAB9A 3212/4885SMN1; SMN2 2270/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.