HMBS — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL8208273	0.92	2/20
SCHEMBL28322265	0.92	2/20
SCHEMBL28896011	0.92	2/20
SCHEMBL23253259	0.32	2/20
SCHEMBL8721450	0.79	1/20
SCHEMBL27346645	0.79	1/20
SCHEMBL27925642	0.79	1/20
Methylene Chloride (SCHEMBL28249228)	0.78	1/20
SCHEMBL27806212	0.73	1/20
SCHEMBL28769398	0.69	1/20
SCHEMBL12141823	0.67	1/20
SCHEMBL19338014	0.67	1/20
Formic Acid (SCHEMBL27731395)	0.65	1/20
Pyrrole (SCHEMBL28011885)	0.65	1/20
SCHEMBL1104622	0.62	1/20
SCHEMBL10054604	0.62	1/20
SCHEMBL12000745	0.62	1/20
SCHEMBL15788744	0.62	1/20
SCHEMBL2316011	0.61	1/20
SCHEMBL8716810	0.61	1/20

Clinical trials — most relevant to HMBS by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of Sevoflurane and Desflurane on Heme Oxygenase-1 Expression in Elective Cholecystectomy	PHASE4	WITHDRAWN
ENVISION: A Study to Evaluate the Efficacy and Safety of Givosiran (ALN-AS1) in Patients With Acute Hepatic Porphyrias (AHP)	PHASE3	COMPLETED
Nitric Oxide for Reduced Intensive Support in Cardiac Surgery With Cardiopulmonary Bypass	PHASE3	RECRUITING
Studies in Porphyria III: Heme and Tin Mesoporphyrin in Acute Porphyrias	PHASE2	COMPLETED
A Phase 1/2 Study to Investigate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of HMB-001 in Glanzmann Thrombasthenia	PHASE1/PHASE2	ACTIVE_NOT_RECRUITING
Does Heme Oxygenase-1 Induction Ameliorate Cardiac Injury After Myocardial Infarction?	PHASE1/PHASE2	COMPLETED
Liver Cancer Prevention Trial in Patients With Chronic Hep C Infection	PHASE2	COMPLETED
Effect of Oral Cimetidine in the Protoporphyrias	PHASE2	COMPLETED
Can Recombinant Human Intrinsic Factor Be Used for Evaluation of the Vitamin B12 Absorption?	PHASE2	COMPLETED
Efficacy of Sunlight Activated Synthetic Porphyrin in COVID-19 Infected Patients	PHASE1	UNKNOWN
Hemin in Healthy Subjects	PHASE1	COMPLETED
A Dose-Finding Study of AG-348 in Sickle Cell Disease	EARLY_PHASE1	COMPLETED
Colombia National Porphyria Registry	nan	UNKNOWN
Studies in Porphyria I: Characterization of Enzyme Defects	nan	UNKNOWN
Observational Study of Acute Intermittent Porphyria Patients	nan	COMPLETED
Dental Health, Diet, Inflammation and Biomarkers in Patients With Acute Intermittent Porphyria(AIP)	nan	UNKNOWN
Longitudinal Study of the Porphyrias	nan	RECRUITING
Erythropoietic Protoporphyrias: Studies of the Natural History, Genotype-Phenotype Correlations, and Psychosocial Impact	nan	COMPLETED
Identification of Acute Intermittent Porphyria Modifying Genes	nan	RECRUITING
Prevalence of Acute Hepatic Porphyria	nan	COMPLETED
Interaction of Cobalamin Status With Nitrous Oxide in Relation to Postoperative Cognitive Changes in the Elderly	nan	COMPLETED
Clinical Diagnosis of Acute Porphyria	nan	COMPLETED
Relationship of Haptoglobin Phenotype to Vascular Function and Response to Vitamin E Supplementation in Patients With Diabetes Mellitus Type 2: The EVAS Trial	nan	UNKNOWN
Role of a Dietary Supplement in Lowering SAH in Healthy Adults With Elevated Plasma SAH and Normal Homocysteine Levels	nan	COMPLETED
Early Nutritional Intervention in Patients With Autism Spectrum Disorders	nan	COMPLETED
Acute Porphyria Biomarkers for Disease Activity	nan	ACTIVE_NOT_RECRUITING
Homocysteine and Coronary Artery Disease	nan	COMPLETED
Plasma Holotranscobalamin as Compared to Plasma Cobalamins for Assessment of Vitamin B12 Absorption	nan	COMPLETED
Mitoferrin-1 Expression in Erythropoietic Protoporphyria (Porphyria Rare Disease Clinical Research Consortium (RDCRC))	nan	COMPLETED
Pilot Study to Evaluate the Safety, Tolerability, and Efficacy of 5-ALA-Phosphate + SFC in Subjects With COVID-19	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a HMBS binder may also engage these)

Protein	Name	Similarity
Q2KIN5	—	1.000	Q2KIN5 →
P19356	—	1.000	P19356 →
P22907	—	0.999	P22907 →
O04226	—	0.974	O04226 →
O04015	—	0.973	O04015 →
Q96480	—	0.972	Q96480 →
P32296	—	0.969	P32296 →
O65361	—	0.969	O65361 →
Q29554	—	0.968	Q29554 →
A4G9J2	—	0.968	A4G9J2 →
P33280	—	0.967	P33280 →
E9QI36	—	0.966	E9QI36 →
P54887	—	0.966	P54887 →
P70076	—	0.965	P70076 →
Q61035	—	0.965	Q61035 →
P0DN31	—	0.965	P0DN31 →
Q64428	—	0.964	Q64428 →
Q5R4R2	—	0.964	Q5R4R2 →
B3R7A1	—	0.964	B3R7A1 →
Q6MW51	—	0.964	Q6MW51 →
Q27601	—	0.963	Q27601 →
Q9WUM5	—	0.962	Q9WUM5 →
A6T382	—	0.962	A6T382 →
Q8BMS1	—	0.962	Q8BMS1 →
HADHA	Trifunctional enzyme subunit alpha, mitochondrial	0.962	landscape →
P54888	—	0.962	P54888 →
Q642Q1	—	0.962	Q642Q1 →
UBA2	SUMO-activating enzyme subunit 2	0.962	landscape →
Q93Z70	—	0.962	Q93Z70 →
Q6AV34	—	0.962	Q6AV34 →