Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 12/20 | 0.63 |
| ▸ | MET | P08581 | 8/20 | 0.63 |
| ▸ | MERTK | Q12866 | 5/20 | 0.63 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.63 |
| ▸ | FLT1 | P17948 | 3/20 | 0.63 |
| ▸ | KDR | P35968 | 3/20 | 0.63 |
| ▸ | FLT3 | P36888 | 2/20 | 0.63 |
| ▸ | AURKA | O14965 | 1/20 | 0.63 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.63 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.63 |
| ▸ | ABL1 | P00519 | 1/20 | 0.63 |
| ▸ | EGFR | P00533 | 1/20 | 0.63 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.63 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.63 |
| ▸ | LCK | P06239 | 1/20 | 0.63 |
| ▸ | PGR | P06401 | 1/20 | 0.63 |
| ▸ | LYN | P07948 | 1/20 | 0.63 |
| ▸ | RET | P07949 | 1/20 | 0.63 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.63 |
| ▸ | HCK | P08631 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL371810 | 0.93 | AXL (0.73) | AXLMETMERTKAURKBFLT1 | |
| SCHEMBL29693454 | 0.93 | AXL (0.73) | AXLMETMERTKAURKBFLT1 | |
| SCHEMBL17433337 | 0.85 | AXL (0.84) | AXLMETMERTKAURKBFLT1 | |
| SCHEMBL24444625 | 0.85 | AXL (0.71) | AXLMETMERTKAURKBFLT1 | |
| SCHEMBL15765565 | 0.83 | MET (0.69) | AXLMETMERTKAURKBFLT1 | |
| SCHEMBL24444553 | 0.83 | AXL (0.72) | AXLMETMERTKAURKBFLT1 | |
| SCHEMBL371732 | 0.82 | MET (0.80) | AXLMETMERTKAURKBFLT1 | |
| SCHEMBL19373350 | 0.82 | AXL (0.64) | AXLMETMERTKAURKBFLT1 | |
| SCHEMBL19373328 | 0.81 | AXL (0.73) | AXLMETMERTKAURKBFLT1 | |
| SCHEMBL19373358 | 0.81 | MET (0.88) | AXLMETMERTKAURKBFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3329918-B1 | C-MET MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2022-05-25 | — | — | EP | disclosed |