SCHEMBL24449284

SCHEMBL24449284

CN1CCN(Cc2ccc(NC(=O)Nc3ccc(-c4cnn(-c5ccncc5)c4)cc3)cc2C(F)(F)F)CC1

nearest known ligand 0.68

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ SRC P12931 6/20 0.68
▸ FGFR4 P22455 5/20 0.63
▸ RET P07949 3/20 0.56
▸ KDR P35968 2/20 0.56
▸ ABL1 P00519 6/20 0.56
▸ BRAF P15056 1/20 0.55
▸ CDK1 P06493 1/20 0.54
▸ CDK2 P24941 1/20 0.54
▸ CDK8 P49336 1/20 0.54
▸ MKNK2 Q9HBH9 1/20 0.53
▸ ABL2 P42684 1/20 0.53
▸ CSF1R P07333 1/20 0.52
▸ KIT P10721 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24449129 0.93 FGFR4 (0.64) SRCFGFR4RETKDRABL1
SCHEMBL24448277 0.91 SRC (0.60) SRCFGFR4RETKDRABL1
SCHEMBL24449096 0.90 FGFR4 (0.61) SRCFGFR4RETKDRABL1
SCHEMBL24449095 0.87 FGFR4 (0.61) SRCFGFR4RETKDRABL1
SCHEMBL24449233 0.86 FGFR4 (0.60) SRCFGFR4RETKDRABL1
SCHEMBL24449287 0.84 ABL1 (0.59) SRCFGFR4RETKDRABL1
SCHEMBL24449288 0.83 FGFR4 (0.57) SRCFGFR4RETKDRABL1
SCHEMBL19911109 0.81 SRC (1.00) SRCFGFR4RETKDRABL1
SCHEMBL3852698 0.78 SRC (0.61) SRCFGFR4RETKDRABL1
SCHEMBL24161134 0.78 KIT (0.66) RETABL1BRAFCSF1RKIT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220160705-A1 METHODS FOR CONTROLLING PROSTAGLANDIN-MEDIATED BIOLOGICAL PROCESSES CORNELL UNIVERSITY 2022-05-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220160705-A1 METHODS FOR CONTROLLING PROSTAGLANDIN-MEDIATED BIOLOGICAL PROCESSES PTGES, PTGS1, PTGES2 SRC 4369/4885FGFR4 4833/4885RET 4879/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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