Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.41 |
| ▸ | AHR | P35869 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | CCR8 | P51685 | 1/20 | 0.36 |
| ▸ | METAP1 | P53582 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.36 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7454285 | 0.91 | SMN1; SMN2 (0.52) | SMN1; SMN2L3MBTL1CHRM2AHRBLM | |
| SCHEMBL5148545 | 0.81 | SMN1; SMN2 (0.50) | SMN1; SMN2L3MBTL1CHRM2AHRBLM | |
| SCHEMBL31174998 | 0.79 | SMN1; SMN2 (0.48) | SMN1; SMN2L3MBTL1CHRM2AHRBLM | |
| SCHEMBL19222207 | 0.78 | SMN1; SMN2 (0.47) | SMN1; SMN2L3MBTL1CHRM2AHRBLM | |
| SCHEMBL21742282 | 0.76 | CHRM2 (0.46) | SMN1; SMN2L3MBTL1CHRM2AHRBLM | |
| SCHEMBL24380350 | 0.76 | SMN1; SMN2 (0.45) | SMN1; SMN2L3MBTL1CHRM2AHRBLM | |
| SCHEMBL4388586 | 0.76 | SMN1; SMN2 (0.67) | SMN1; SMN2L3MBTL1CHRM2AHRBLM | |
| SCHEMBL678325 | 0.76 | SMN1; SMN2 (0.54) | SMN1; SMN2L3MBTL1CHRM2AHRBLM | |
| SCHEMBL3076392 | 0.76 | SMN1; SMN2 (0.54) | SMN1; SMN2L3MBTL1CHRM2AHRBLM | |
| SCHEMBL29080 | 0.75 | SMN1; SMN2 (0.58) | SMN1; SMN2L3MBTL1CHRM2AHRBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220402926-A1 | NOVEL MACROCYCLIC SPIROPYRROLIDINE DERIVED ANTIVIRAL AGENTS | ENANTA PHARMACEUTICALS, INC. | 2022-12-22 | — | — | US | disclosed |
| US-20220162231-A1 | NOVEL SPIROPYRROLIDINE DERIVED ANTIVIRAL AGENTS | ENANTA PHARMACEUTICALS, INC. | 2022-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220402926-A1 | NOVEL MACROCYCLIC SPIROPYRROLIDINE DERIVED ANTIVIRAL AGENTS | ACE, ACE2, PKD1 | SMN1; SMN2 2757/4885L3MBTL1 4797/4885CHRM2 4760/4885 |
| US-20220162231-A1 | NOVEL SPIROPYRROLIDINE DERIVED ANTIVIRAL AGENTS | ACE, ACE2, PKD1 | SMN1; SMN2 3361/4885L3MBTL1 4851/4885CHRM2 4506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.