Sugi Predict

Sugi Predict / Compounds / SCHEMBL24449795

SCHEMBL24449795

SCHEMBL24449795

CCNC(=O)N1CC(CC(C)(C)C)C1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 2/20 0.53
▸ HTT P42858 1/20 0.46
▸ DPP4 P27487 1/20 0.38
▸ NAMPT P43490 1/20 0.36
▸ LMNA P02545 1/20 0.36
▸ CHRNB2 P17787 2/20 0.34
▸ CHRNB4 P30926 2/20 0.34
▸ CHRNA3 P32297 2/20 0.34
▸ CHRNA7 P36544 2/20 0.34
▸ CHRNA4 P43681 2/20 0.34
▸ MAPK1 P28482 2/20 0.33
▸ ALDH1A1 P00352 1/20 0.33
▸ APOL1 O14791 1/20 0.33
▸ BRD4 O60885 1/20 0.33
▸ TACR1 P25103 1/20 0.33
▸ POLB P06746 1/20 0.33
▸ FAAH O00519 1/20 0.33
▸ CYP3A4 P08684 1/20 0.33
▸ CYP2D6 P10635 1/20 0.33
▸ TSHR P16473 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24449427 0.86 KMT2A (0.52) KMT2AHTTLMNAMAPK1ALDH1A1
SCHEMBL24448833 0.86 KMT2A (0.52) KMT2AHTTLMNAMAPK1ALDH1A1
SCHEMBL24448839 0.86 KMT2A (0.52) KMT2AHTTLMNAMAPK1ALDH1A1
SCHEMBL24449554 0.84 LMNA (0.49) KMT2AHTTLMNAMAPK1ALDH1A1
SCHEMBL24449434 0.82 KMT2A (0.46) KMT2AHTTDPP4NAMPTLMNA
SCHEMBL21025690 0.81 POLB (0.46) NAMPTLMNAPOLBTHRATHRB
SCHEMBL24449753 0.79 LMNA (0.47) NAMPTLMNAALDH1A1TACR1CYP2D6
SCHEMBL15298478 0.79 KMT2A (0.55) KMT2AHTTDPP4LMNACHRNB2
SCHEMBL24449467 0.76 KMT2A (0.52) KMT2AHTTDPP4NAMPTLMNA
SCHEMBL20615648 0.76 KMT2A (0.52) KMT2AHTTDPP4LMNACHRNB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230357208-A1 MYST FAMILY HISTONE ACETYLTRANSFERASE INHIBITORS Epizyme, Inc. (US) 2023-11-09 — — US disclosed
US-20230357208-A1 MYST FAMILY HISTONE ACETYLTRANSFERASE INHIBITORS Epizyme, Inc. (US) 2023-11-09 — — US disclosed
US-11685732-B2 MYST family histone acetyltransferase inhibitors Epizyme, Inc. (US) 2023-06-27 — — US disclosed
US-11685732-B2 MYST family histone acetyltransferase inhibitors Epizyme, Inc. (US) 2023-06-27 — — US disclosed
US-20220162197-A1 MYST FAMILY HISTONE ACETYLTRANSFERASE INHIBITORS Epizyme, Inc. 2022-05-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220162197-A1 MYST FAMILY HISTONE ACETYLTRANSFERASE INHIBITORS EP300, KAT2A, KAT6A KMT2A 33/4885HTT 647/4885DPP4 3131/4885
US-20230357208-A1 MYST FAMILY HISTONE ACETYLTRANSFERASE INHIBITORS EP300, KAT2A, KAT6A KMT2A 33/4885HTT 647/4885DPP4 3131/4885
US-11685732-B2 MYST family histone acetyltransferase inhibitors EP300, KAT2A, KAT6A KMT2A 33/4885HTT 647/4885DPP4 3131/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.