Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 19/20 | 0.80 |
| ▸ | HSD17B2 | P37059 | 18/20 | 0.80 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23779 | 0.92 | HSD17B2 (0.67) | HSD17B1HSD17B2HDAC6 | |
| SCHEMBL23202 | 0.90 | HSD17B2 (0.70) | HSD17B1HSD17B2 | |
| SCHEMBL30843 | 0.90 | HSD17B2 (0.75) | HSD17B1HSD17B2 | |
| SCHEMBL23010 | 0.88 | HSD17B1 (0.70) | HSD17B1HSD17B2 | |
| SCHEMBL22549 | 0.88 | HSD17B2 (0.70) | HSD17B1HSD17B2 | |
| SCHEMBL18195278 | 0.87 | HSD17B2 (0.65) | HSD17B1HSD17B2HDAC6 | |
| SCHEMBL22914 | 0.87 | HSD17B1 (0.78) | HSD17B1HSD17B2 | |
| SCHEMBL24263 | 0.87 | HSD17B1 (1.00) | HSD17B1HSD17B2 | |
| SCHEMBL23361 | 0.86 | HDAC6 (0.66) | HSD17B1HSD17B2HDAC6 | |
| SCHEMBL23125 | 0.84 | HSD17B2 (0.65) | HSD17B1HSD17B2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609089-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2013-07-03 | — | — | EP | claimed |
| WO-2012025638-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2012-03-01 | — | — | WO | claimed |
| EP-2609089-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012025638-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2012-03-01 | — | — | WO | disclosed |