Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.43 |
| ▸ | TP53 | P04637 | 11/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL496230 | 1.00 | MAPT (0.43) | MAPTTP53LMNASMN1; SMN2RXFP1 | |
| SCHEMBL496264 | 0.84 | MAPT (0.42) | MAPTTP53LMNASMN1; SMN2RXFP1 | |
| SCHEMBL3671608 | 0.82 | KDM4E (0.34) | — | |
| SCHEMBL496213 | 0.80 | CYP3A4 (0.47) | — | |
| SCHEMBL496329 | 0.80 | HIF1A (0.43) | — | |
| SCHEMBL3668373 | 0.78 | ROCK1 (0.35) | MAPTLMNA | |
| SCHEMBL496277 | 0.74 | TP53 (0.39) | MAPTTP53SMN1; SMN2 | |
| SCHEMBL24898755 | 0.70 | MAPT (0.60) | MAPTTP53LMNASMN1; SMN2RXFP1 | |
| SCHEMBL8209794 | 0.69 | MAPT (0.50) | MAPTSMN1; SMN2 | |
| SCHEMBL496292 | 0.69 | HCRTR1 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2164847-B1 | 3-AZA-BICYCLO[3.3.0]OCTANE COMPOUNDS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-09-14 | — | — | EP | disclosed |