Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 5/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 2/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.30 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.30 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31741734 | 0.86 | ALDH1A1 (0.36) | KDM5BKDM5AALDH1A1KMT2APOLB | |
| SCHEMBL14903851 | 0.81 | KMT2A (0.38) | KDM5BKDM5AALDH1A1KMT2APOLB | |
| SCHEMBL23290691 | 0.78 | KMT2A (0.38) | KDM5BALDH1A1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL38651558 | 0.78 | ALDH1A1 (0.38) | KDM5BALDH1A1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL25189871 | 0.78 | ALDH1A1 (0.38) | KDM5BALDH1A1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL1475184 | 0.77 | ALDH1A1 (0.36) | KDM5BALDH1A1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL28999288 | 0.77 | EPHX2 (0.39) | KDM5BALDH1A1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL21639199 | 0.77 | ALDH1A1 (0.38) | KDM5BKDM5AALDH1A1KMT2APOLB | |
| SCHEMBL29576159 | 0.76 | ABL1 (0.38) | KDM5BRETCYP2C19FLT3SYK | |
| SCHEMBL24456256 | 0.76 | KDM5B (0.33) | KDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022109492-A1 | PYRROLOPYRIDAZINE COMPOUNDS AS KINASE INHIBITORS | GOSSAMER BIOSERVICES, INC. (US) | 2022-05-27 | — | — | WO | disclosed |