Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.50 |
| ▸ | CA5A | P35218 | 2/20 | 0.50 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.50 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.50 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.50 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.50 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.50 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.50 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL8300104 | 1.00 | TSHR (0.50) | TSHRCA5ACA5BGABRA1GABRG2 | |
| Sulfuric Acid SCHEMBL6260312 | 1.00 | TSHR (0.50) | TSHRCA5ACA5BGABRA1GABRG2 | |
| Sulfuric Acid SCHEMBL6099988 | 1.00 | TSHR (0.50) | TSHRCA5ACA5BGABRA1GABRG2 | |
| Sulfuric Acid SCHEMBL6099992 | 1.00 | TSHR (0.50) | TSHRCA5ACA5BGABRA1GABRG2 | |
| Sulfuric Acid SCHEMBL8291975 | 1.00 | TSHR (0.50) | TSHRCA5ACA5BGABRA1GABRG2 | |
| Piperazine SCHEMBL5875243 | 1.00 | TSHR (0.50) | TSHRCA5ACA5BGABRA1GABRG2 | |
| Piperazine SCHEMBL27978492 | 1.00 | TSHR (0.50) | TSHRCA5ACA5BGABRA1GABRG2 | |
| Piperazine SCHEMBL30708072 | 0.96 | TSHR (0.48) | TSHRCA5ACA5BGABRA1GABRG2 | |
| Piperazine SCHEMBL30517943 | 0.96 | TSHR (0.48) | TSHRCA5ACA5BGABRA1GABRG2 | |
| Sulfuric Acid SCHEMBL4097784 | 0.96 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 146 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220355148-A1 | Phosphorous-Nitrogen Alternative to PFC Foam | KASOWSKI ROBERT VALENTINE (US) | 2022-11-10 | — | — | US | claimed |
| EP-4034261-A1 | PHOSPHORUS-NITROGEN ALTERNATIVE TO PFC FOAM | Kasowski, Robert Valentine (US) | 2022-08-03 | — | — | EP | claimed |
| CN-114514052-A | Phosphorus nitrogen substitute for PFC foam | 罗伯特·瓦伦丁·卡索斯基 | 2022-05-17 | — | — | CN | claimed |
| WO-2021061677-A1 | PHOSPHORUS-NITROGEN ALTERNATIVE TO PFC FOAM | KASOWSKI ROBERT VALENTINE (US) | 2021-04-01 | — | — | WO | claimed |
| CN-103638779-B | A kind of renewable organic amine fume desulfurizing agent and preparation method thereof | HEFEI UNIVERSITY OF TECHNOLOGY (CN) | 2015-08-12 | — | — | CN | claimed |
| CN-103638779-A | Renewable organic amine flue gas desulfurization agent and preparation method thereof | UNIV HEFEI TECHNOLOGY | 2014-03-19 | — | — | CN | claimed |
| EP-2450412-A1 | Silicone coating composition | AZ Electronic Materials USA Corp. (US) | 2012-05-09 | — | — | EP | claimed |
| EP-2121857-A1 | SILICONE COATING COMPOSITION | AZ Electronic Materials USA Corp. (US) | 2009-11-25 | — | — | EP | claimed |
| WO-2008102256-A1 | SILICONE COATING COMPOSITION | AZ ELECTRONIC MATERIALS USA CORP. (DE) | 2008-08-28 | — | — | WO | claimed |
| US-20080196626-A1 | High silicon-content resin composition used to form thin film thermosets; form low k dielectric constant materials; hard mask and underlayer materials with anti-reflective properties for photolithography industry | MERCK PATENT GMBH (DE) | 2008-08-21 | — | — | US | claimed |
| US-6971945-B2 | Multi-step polishing solution for chemical mechanical planarization | ROHM AND HAAS ELECTRONIC MATERIALS CMP HOLDINGS, INC. (US) | 2005-12-06 | — | — | US | claimed |
| US-20050194357-A1 | MULTI-STEP POLISHING SOLUTION FOR CHEMICAL MECHANICAL PLANARIZATION | ROHM AND HAAS ELECTRONIC MATERIALS CMP HOLDINGS, INC. | 2005-09-08 | — | — | US | claimed |
| WO-2003082299-A1 | IMPROVED HORMONE REPLACEMENT THERAPY | JENCAP RESEARCH LTD. (CA) | 2003-10-09 | — | — | WO | claimed |
| EP-0601353-A2 | Process for the production of N-(2-Sulphatoethyl) piperazine with a high purity | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-06-15 | — | — | EP | claimed |
| EP-3166981-B1 | OLIGOSACCHARIDE COMPOSITIONS AND METHODS FOR PRODUCING THEREOF | DSM NUTRITIONAL PRODUCTS LLC (US) | 2026-05-13 | — | — | EP | disclosed |
| US-12514267-B2 | Oligosaccharide compositions for use as animal feed and methods of producing thereof | DSM NUTRITIONAL PRODUCTS, LLC (US) | 2026-01-06 | — | — | US | disclosed |
| CN-120078779-A | Composition for inhibiting herpesvirus | 威斯康星州医药大学股份有限公司 | 2025-06-03 | — | — | CN | disclosed |
| CN-85100949-A | The synthetic gene of bovine parainfluenza virus | — | 1987-01-10 | — | — | CN | disclosed |
| US-4319024-A | ALKYLATION | DYNAMIT NOBEL AKTIENGESELLSCHAFT (DE) | 1982-03-09 | — | — | US | disclosed |
| US-4206088-A | ACID /ADDITION SALT OF ORGANONITROGEN BASE ABOSRBED ON SOLID INORGANIC ACID | MITA INDUSTRIAL COMPANY LIMITED (JP) | 1980-06-03 | — | — | US | disclosed |