Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.50 |
| ▸ | CA5A | P35218 | 2/20 | 0.50 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.50 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.50 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.50 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.50 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.50 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.50 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL8300104 | 1.00 | TSHR (0.50) | TSHRCA5ACA5BGABRA1GABRG2 | |
| Sulfuric Acid SCHEMBL6260312 | 1.00 | TSHR (0.50) | TSHRCA5ACA5BGABRA1GABRG2 | |
| Sulfuric Acid SCHEMBL6099988 | 1.00 | TSHR (0.50) | TSHRCA5ACA5BGABRA1GABRG2 | |
| Sulfuric Acid SCHEMBL6099992 | 1.00 | TSHR (0.50) | TSHRCA5ACA5BGABRA1GABRG2 | |
| Sulfuric Acid SCHEMBL8291975 | 1.00 | TSHR (0.50) | TSHRCA5ACA5BGABRA1GABRG2 | |
| Piperazine SCHEMBL27978492 | 1.00 | TSHR (0.50) | TSHRCA5ACA5BGABRA1GABRG2 | |
| Piperazine SCHEMBL2445779 | 1.00 | TSHR (0.50) | TSHRCA5ACA5BGABRA1GABRG2 | |
| Piperazine SCHEMBL30708072 | 0.96 | TSHR (0.48) | TSHRCA5ACA5BGABRA1GABRG2 | |
| Piperazine SCHEMBL30517943 | 0.96 | TSHR (0.48) | TSHRCA5ACA5BGABRA1GABRG2 | |
| Sulfuric Acid SCHEMBL4097784 | 0.96 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023126969-A1 | ORAL FILMS OF ANIT-PARASITIC DRUGS | LAURUS LABS LIMITED (IN) | 2023-07-06 | — | — | WO | disclosed |
| CN-111683653-A | Methods and compositions for topical delivery | 伊拉斯吹斯制药有限公司 | 2020-09-18 | — | — | CN | disclosed |
| EP-3694489-A2 | METHODS AND COMPOSITIONS FOR TOPICAL DELIVERY | Illustris Pharmaceuticals, Inc. (US) | 2020-08-19 | — | — | EP | disclosed |
| WO-2019075263-A2 | METHODS AND COMPOSITIONS FOR TOPICAL DELIVERY | ILLUSTRIS PHARMACEUTICALS, INC. (US) | 2019-04-18 | — | — | WO | disclosed |
| US-20190105261-A1 | METHODS AND COMPOSITIONS FOR TOPICAL DELIVERY | ILLUSTRIS PHARMACEUTICALS, INC. | 2019-04-11 | — | — | US | disclosed |
| EP-3442488-A1 | COMPOSITIONS FOR TOPICAL APPLICATION OF COMPOUNDS | Illustris Pharmaceuticals, Inc. (US) | 2019-02-20 | — | — | EP | disclosed |
| US-20190008795-A1 | COMPOSITIONS FOR TOPICAL APPLICATION OF COMPOUNDS | ILLUSTRIS PHARMACEUTICALS, INC. | 2019-01-10 | — | — | US | disclosed |
| CN-109152702-A | COMPOSITIONS FOR TOPICAL APPLICATION OF COMPOUNDS | 伊拉斯吹斯制药有限公司 | 2019-01-04 | — | — | CN | disclosed |
| WO-2017180788-A1 | COMPOSITIONS FOR TOPICAL APPLICATION OF COMPOUNDS | ILLUSTRIS PHARMACEUTICALS, INC. (US) | 2017-10-19 | — | — | WO | disclosed |
| US-20170290778-A1 | COMPOSITIONS FOR TOPICAL APPLICATION OF COMPOUNDS | ILLUSTRIS PHARMACEUTICALS, INC. | 2017-10-12 | — | — | US | disclosed |
| US-7128976-B2 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2006-10-31 | — | — | US | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |
| EP-0789080-A2 | Process for the preparation of organic aminium lactates and their use in the preparation of dilactide | Gesellschaft für ökologische Technologie und Systemanalyse e.V. (DE) | 1997-08-13 | — | — | EP | disclosed |