Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.39 |
| ▸ | JAK1 | P23458 | 6/20 | 0.37 |
| ▸ | JAK3 | P52333 | 4/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.36 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25068977 | 1.00 | PRMT5 (0.51) | PRMT5PIK3CDJAK1JAK3JAK2 | |
| SCHEMBL24458124 | 0.88 | JAK1 (0.47) | PRMT5JAK1JAK3JAK2HSD11B1 | |
| SCHEMBL23409153 | 0.88 | JAK1 (0.47) | PRMT5JAK1JAK3JAK2HSD11B1 | |
| SCHEMBL24457922 | 0.87 | PRMT5 (0.50) | PRMT5JAK1JAK3JAK2PSMB8 | |
| SCHEMBL24457962 | 0.87 | PRMT5 (0.50) | PRMT5JAK1JAK3JAK2PSMB8 | |
| SCHEMBL23408954 | 0.87 | PRMT5 (0.50) | PRMT5JAK1JAK3JAK2PSMB8 | |
| SCHEMBL27020925 | 0.85 | PRMT5 (0.45) | PRMT5PIK3CDHSD11B1HCAR1OPRM1 | |
| SCHEMBL27020007 | 0.85 | PRMT5 (0.45) | PRMT5PIK3CDHSD11B1HCAR1OPRM1 | |
| SCHEMBL25068976 | 0.85 | PRMT5 (0.45) | PRMT5PIK3CDHSD11B1HCAR1OPRM1 | |
| SCHEMBL25068871 | 0.83 | CCNT1 (0.48) | PRMT5PIK3CDJAK1JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240018153-A1 | BENZENESULFONAMIDE DERIVATIVES AND USES THEREOF | 2692372 ONTARIO, INC. (CA) | 2024-01-18 | — | — | US | disclosed |
| WO-2022106902-A2 | BENZENESULFONAMIDE DERIVATIVES AND USES THEREOF | 2692372 ONTARIO, INC. (CA) | 2022-05-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240018153-A1 | BENZENESULFONAMIDE DERIVATIVES AND USES THEREOF | ABCG2, ABCB1, ARSA | PRMT5 3577/4885PIK3CD 3061/4885JAK1 1623/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.