Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 14/20 | 0.47 |
| ▸ | JAK3 | P52333 | 5/20 | 0.47 |
| ▸ | JAK2 | O60674 | 3/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24458124 | 1.00 | JAK1 (0.47) | JAK1JAK3JAK2CCNT1CDK9 | |
| SCHEMBL12791679 | 0.88 | CDK9 (0.57) | JAK1JAK2CCNT1CDK9GAA | |
| SCHEMBL24458045 | 0.88 | PRMT5 (0.51) | JAK1JAK3JAK2GAAHSD11B1 | |
| SCHEMBL25068977 | 0.88 | PRMT5 (0.51) | JAK1JAK3JAK2GAAHSD11B1 | |
| SCHEMBL23409085 | 0.86 | JAK1 (0.51) | JAK1JAK3JAK2CCNT1CDK9 | |
| SCHEMBL27020009 | 0.85 | CCNT1 (0.48) | JAK1JAK3JAK2CCNT1CDK9 | |
| SCHEMBL25068871 | 0.85 | CCNT1 (0.48) | JAK1JAK3JAK2CCNT1CDK9 | |
| SCHEMBL27019894 | 0.76 | HSD11B1 (0.42) | JAK1JAK3JAK2CCNT1CDK9 | |
| SCHEMBL24457962 | 0.74 | PRMT5 (0.50) | JAK1JAK3JAK2HSD11B1PRMT5 | |
| SCHEMBL23408954 | 0.74 | PRMT5 (0.50) | JAK1JAK3JAK2HSD11B1PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021099842-A1 | PENTAFLUOROBENZENESULFONAMIDE DERIVATIVES AND USES THEREOF | 2692372 ONTARIO INC. (CA) | 2021-05-27 | — | — | WO | disclosed |