Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | SCN4A | P35499 | 4/20 | 0.39 |
| ▸ | PDE4A | P27815 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12636264 | 0.82 | DHFR (0.42) | MAPTKMT2ACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL6407105 | 0.82 | KMT2A (0.61) | MAPTKMT2ACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL20362610 | 0.80 | MAPT (0.47) | MAPTKMT2APDE4APDE4BPDE4C | |
| SCHEMBL19872533 | 0.79 | MAPT (0.43) | MAPTKMT2ACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL4932262 | 0.79 | KMT2A (0.46) | MAPTKMT2ACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL15054521 | 0.79 | MAPT (0.43) | MAPTKMT2ACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL10863911 | 0.79 | CYP3A4 (0.46) | MAPTKMT2ACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL12504651 | 0.79 | SCN4A (0.44) | MAPTKMT2ASCN4ASMN1; SMN2L3MBTL1 | |
| SCHEMBL10734341 | 0.78 | MAPT (0.46) | MAPTCYP1A2PDE4APDE4BPDE4C | |
| SCHEMBL416315 | 0.78 | GAA (0.55) | KMT2ACYP1A2CYP2D6CYP2C9SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022109001-A1 | GCN2 AND PERK KINASE INHIBITORS AND METHODS OF USE THEREOF | DECIPHERA PHARMACEUTICALS, LLC (US) | 2022-05-27 | — | — | WO | disclosed |