Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.47 |
| ▸ | BLK | P51451 | 3/20 | 0.42 |
| ▸ | EGFR | P00533 | 3/20 | 0.42 |
| ▸ | ITK | Q08881 | 3/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.42 |
| ▸ | TEC | P42680 | 2/20 | 0.42 |
| ▸ | BMX | P51813 | 2/20 | 0.42 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | TXK | P42681 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | YES1 | P07947 | 1/20 | 0.37 |
| ▸ | LYN | P07948 | 1/20 | 0.37 |
| ▸ | HCK | P08631 | 1/20 | 0.37 |
| ▸ | FGR | P09769 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31523720 | 1.00 | BTK (0.47) | BTKBLKEGFRITKERBB2 | |
| SCHEMBL24458913 | 0.91 | BTK (0.56) | BTKBLKEGFRITKERBB2 | |
| SCHEMBL31523943 | 0.91 | BTK (0.56) | BTKBLKEGFRITKERBB2 | |
| SCHEMBL31523783 | 0.90 | BTK (0.39) | BTKBLKEGFRITKERBB2 | |
| SCHEMBL24458677 | 0.90 | BTK (0.39) | BTKBLKEGFRITKERBB2 | |
| SCHEMBL24458921 | 0.89 | BTK (0.43) | BTKEGFRTECBMXTXK | |
| SCHEMBL31523769 | 0.89 | BTK (0.43) | BTKEGFRTECBMXTXK | |
| SCHEMBL24458649 | 0.84 | BTK (0.38) | BTKEGFRITKLCKJAK3 | |
| SCHEMBL31523722 | 0.84 | BTK (0.38) | BTKEGFRITKLCKJAK3 | |
| SCHEMBL24459065 | 0.82 | BTK (0.48) | BTKEGFRITKLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022109551-A1 | SRC INHIBITORS AND USES THEREOF | RELAY THERAPEUTICS, INC. (US) | 2022-05-27 | — | — | WO | disclosed |