Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 12/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | ITK | Q08881 | 1/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.44 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | HCK | P08631 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | BLK | P51451 | 1/20 | 0.43 |
| ▸ | BMX | P51813 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31523732 | 1.00 | BTK (0.48) | BTKEGFRITKFGFR2FGFR1 | |
| SCHEMBL24458468 | 0.91 | BTK (0.57) | BTKEGFRITKFGFR2KDR | |
| SCHEMBL31523740 | 0.90 | ITK (0.43) | BTKEGFRITKFGFR2FGFR1 | |
| SCHEMBL24458406 | 0.89 | RET (0.47) | BTKEGFRITKFGFR2FGFR1 | |
| SCHEMBL24458529 | 0.88 | BTK (0.45) | BTKEGFRFGFR2ERBB3KDR | |
| SCHEMBL31523738 | 0.88 | BTK (0.45) | BTKEGFRFGFR2ERBB3KDR | |
| SCHEMBL24459042 | 0.88 | BTK (0.50) | BTKEGFRITKFGFR2FGFR1 | |
| SCHEMBL24458910 | 0.85 | ITK (0.43) | BTKEGFRITKFGFR2FGFR1 | |
| SCHEMBL29552575 | 0.84 | RET (0.43) | EGFRITKFGFR2FGFR1FGFR4 | |
| SCHEMBL24458660 | 0.84 | BTK (0.57) | BTKEGFRITKFGFR2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022109551-A1 | SRC INHIBITORS AND USES THEREOF | RELAY THERAPEUTICS, INC. (US) | 2022-05-27 | — | — | WO | disclosed |