Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | KIF5B | P33176 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 6/20 | 0.43 |
| ▸ | ABL1 | P00519 | 4/20 | 0.41 |
| ▸ | EGFR | P00533 | 3/20 | 0.41 |
| ▸ | ABL2 | P42684 | 2/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 8/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 6/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.40 |
| ▸ | ITK | Q08881 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24458406 | 0.94 | RET (0.47) | RETKIF5BEGFRFGFR2FGFR1 | |
| SCHEMBL24459052 | 0.89 | RET (0.43) | RETKIF5BSRCABL1EGFR | |
| SCHEMBL29552163 | 0.89 | RET (0.43) | RETKIF5BSRCABL1EGFR | |
| SCHEMBL31523732 | 0.84 | BTK (0.48) | SRCEGFRFGFR2FGFR1FGFR4 | |
| SCHEMBL24458905 | 0.84 | BTK (0.48) | SRCEGFRFGFR2FGFR1FGFR4 | |
| SCHEMBL24458601 | 0.82 | RET (0.49) | RETKIF5BFGFR2FGFR1FGFR4 | |
| SCHEMBL31523740 | 0.82 | ITK (0.43) | EGFRFGFR2FGFR1FGFR4FGFR3 | |
| SCHEMBL29552493 | 0.82 | RET (0.44) | RETKIF5BSRCABL1EGFR | |
| SCHEMBL24459026 | 0.81 | SRC (0.50) | RETKIF5BSRCABL1EGFR | |
| SCHEMBL29552667 | 0.80 | SRC (0.43) | RETKIF5BSRCABL1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4247816-A1 | SRC INHIBITORS AND USES THEREOF | Relay Therapeutics, Inc. (US) | 2023-09-27 | — | — | EP | disclosed |
| WO-2022109551-A1 | SRC INHIBITORS AND USES THEREOF | RELAY THERAPEUTICS, INC. (US) | 2022-05-27 | — | — | WO | disclosed |