SCHEMBL24459016

SCHEMBL24459016

COc1cc(-c2c(C#CC3CN(C4CCN(C(=O)OC(C)(C)C)[C@H](CO)C4)C3)n(C)c3ncnc(N)c23)ccc1Cl

nearest known ligand 0.48

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ SRC P12931 19/20 0.48
▸ RET P07949 1/20 0.43
▸ KIF5B P33176 1/20 0.43
▸ ABL1 P00519 1/20 0.40
▸ EGFR P00533 1/20 0.40
▸ ABL2 P42684 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29552703 0.95 SRC (0.45) SRCRETKIF5B
SCHEMBL29552045 0.90 RET (0.43) SRCRETKIF5BABL1EGFR
SCHEMBL24458658 0.90 FGFR2 (0.45) SRCRETKIF5B
SCHEMBL24459026 0.89 SRC (0.50) SRCRETKIF5BABL1EGFR
SCHEMBL24458957 0.82 SRC (0.46) SRCRETKIF5BABL1EGFR
SCHEMBL24458601 0.80 RET (0.49) RETKIF5B
SCHEMBL31523763 0.80 FGFR2 (0.44) EGFR
SCHEMBL24459068 0.80 FGFR2 (0.44) EGFR
SCHEMBL29552667 0.79 SRC (0.43) SRCRETKIF5BABL1EGFR
SCHEMBL24458874 0.78 FGFR2 (0.41) SRCEGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250154154-A1 SRC INHIBITORS AND USES THEREOF RELAY THERAPEUTICS, INC. 2025-05-15 — — US disclosed
EP-4247816-A1 SRC INHIBITORS AND USES THEREOF Relay Therapeutics, Inc. (US) 2023-09-27 — — EP disclosed
WO-2022109551-A1 SRC INHIBITORS AND USES THEREOF RELAY THERAPEUTICS, INC. (US) 2022-05-27 — — WO disclosed
WO-2022109551-A1 SRC INHIBITORS AND USES THEREOF RELAY THERAPEUTICS, INC. (US) 2022-05-27 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250154154-A1 SRC INHIBITORS AND USES THEREOF SRC, LCK, FYN SRC 1/4885RET 56/4885KIF5B 1634/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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