Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX1 | P51575 | 8/20 | 0.80 |
| ▸ | TMPRSS4 | Q9NRS4 | 8/20 | 0.80 |
| ▸ | P2RX4 | Q99571 | 4/20 | 0.71 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.71 |
| ▸ | PLAU | P00749 | 2/20 | 0.61 |
| ▸ | F2 | P00734 | 1/20 | 0.61 |
| ▸ | F10 | P00742 | 1/20 | 0.61 |
| ▸ | PLAT | P00750 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | IKBKB | O14920 | 1/20 | 0.56 |
| ▸ | CHUK | O15111 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
| ▸ | MYLK | Q15746 | 1/20 | 0.56 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL132474 | 0.89 | P2RX1 (1.00) | P2RX1TMPRSS4P2RX4P2RX7MEN1 | |
| SCHEMBL25348875 | 0.89 | P2RX1 (0.63) | P2RX1TMPRSS4P2RX4P2RX7PLAU | |
| SCHEMBL21021862 | 0.86 | PLAU (0.73) | P2RX1TMPRSS4PLAUF2F10 | |
| SCHEMBL14394718 | 0.85 | P2RX1 (0.78) | P2RX1TMPRSS4P2RX4P2RX7MEN1 | |
| SCHEMBL14363393 | 0.85 | P2RX1 (0.87) | P2RX1TMPRSS4P2RX4P2RX7PLAU | |
| SCHEMBL18160280 | 0.84 | JAK2 (0.67) | P2RX1TMPRSS4P2RX4P2RX7MEN1 | |
| SCHEMBL24824532 | 0.84 | P2RX1 (0.79) | P2RX1TMPRSS4P2RX4P2RX7MEN1 | |
| SCHEMBL23675372 | 0.84 | P2RX1 (0.85) | P2RX1TMPRSS4P2RX4P2RX7MEN1 | |
| SCHEMBL14363184 | 0.83 | PLAU (0.69) | P2RX1TMPRSS4PLAUF2F10 | |
| SCHEMBL17779272 | 0.83 | P2RX1 (0.71) | P2RX1TMPRSS4P2RX4P2RX7MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022109148-A1 | SMALL MOLECULE INHIBITORS OF SARS-COV-2 INFECTIONS | THE USA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) | 2022-05-27 | — | — | WO | disclosed |