Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 13/20 | 0.39 |
| ▸ | SMARCA2 | P51531 | 12/20 | 0.39 |
| ▸ | SMARCA4 | P51532 | 12/20 | 0.39 |
| ▸ | IKBKB | O14920 | 4/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 8/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30552520 | 1.00 | PBRM1 (0.39) | PBRM1SMARCA2SMARCA4IKBKBNR1I2 | |
| SCHEMBL30552430 | 1.00 | PBRM1 (0.39) | PBRM1SMARCA2SMARCA4IKBKBNR1I2 | |
| SCHEMBL27053152 | 0.88 | PBRM1 (0.38) | PBRM1SMARCA2SMARCA4IKBKBNR1I2 | |
| SCHEMBL24461649 | 0.86 | PBRM1 (0.39) | PBRM1SMARCA2SMARCA4IKBKBNR1I2 | |
| SCHEMBL31505612 | 0.86 | IKBKB (0.39) | PBRM1SMARCA2SMARCA4IKBKBNR1I2 | |
| SCHEMBL30751010 | 0.86 | PBRM1 (0.39) | PBRM1SMARCA2SMARCA4IKBKBNR1I2 | |
| SCHEMBL24461291 | 0.86 | IKBKB (0.39) | PBRM1SMARCA2SMARCA4IKBKBNR1I2 | |
| SCHEMBL24461651 | 0.86 | PBRM1 (0.39) | PBRM1SMARCA2SMARCA4IKBKBNR1I2 | |
| SCHEMBL30750942 | 0.86 | PBRM1 (0.39) | PBRM1SMARCA2SMARCA4IKBKBNR1I2 | |
| SCHEMBL24461357 | 0.85 | IKBKB (0.38) | PBRM1SMARCA2SMARCA4IKBKBNR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240024488-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. | 2024-01-25 | — | — | US | disclosed |
| US-20240024488-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. | 2024-01-25 | — | — | US | disclosed |
| US-20240024488-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. | 2024-01-25 | — | — | US | disclosed |
| EP-4247381-A1 | COMPOUNDS AND USES THEREOF | Foghorn Therapeutics Inc. (US) | 2023-09-27 | — | — | EP | disclosed |
| CN-116744929-A | Compounds and uses thereof | 福霍恩治疗公司 | 2023-09-12 | — | — | CN | disclosed |
| WO-2022109426-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2022-05-27 | — | — | WO | disclosed |
| WO-2022109426-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2022-05-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240024488-A1 | COMPOUNDS AND USES THEREOF | VHL, CLN6, TFEB | PBRM1 18/4885SMARCA2 14/4885SMARCA4 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.