Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK5 | Q8IW41 | 20/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 19/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 18/20 | 0.59 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24461734 | 0.91 | MAPKAPK5 (0.63) | MAPKAPK5MAPK14MAPK1MAPKAPK2 | |
| SCHEMBL24461774 | 0.90 | MAPKAPK5 (0.59) | MAPKAPK5MAPK14MAPK1MAPKAPK2 | |
| SCHEMBL24461776 | 0.90 | MAPKAPK5 (0.59) | MAPKAPK5MAPK14MAPK1MAPKAPK2 | |
| SCHEMBL24461622 | 0.90 | MAPKAPK5 (0.62) | MAPKAPK5MAPK14MAPK1MAPKAPK2 | |
| SCHEMBL24461611 | 0.90 | MAPKAPK5 (0.62) | MAPKAPK5MAPK14MAPK1MAPKAPK2 | |
| SCHEMBL29617119 | 0.90 | MAPKAPK5 (0.64) | MAPKAPK5MAPK14MAPK1MAPKAPK2 | |
| SCHEMBL24461613 | 0.90 | MAPKAPK5 (0.62) | MAPKAPK5MAPK14MAPK1MAPKAPK2 | |
| SCHEMBL23000656 | 0.90 | MAPKAPK5 (0.64) | MAPKAPK5MAPK14MAPK1MAPKAPK2 | |
| SCHEMBL25751761 | 0.88 | MAPK14 (0.61) | MAPK14MAPKAPK2 | |
| SCHEMBL24461796 | 0.87 | MAPKAPK5 (0.59) | MAPKAPK5MAPK14MAPK1MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022109481-A1 | METHODS OF SYNTHESIZING SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | ACLARIS THERAPEUTICS, INC. (US) | 2022-05-27 | — | — | WO | disclosed |