SCHEMBL24465012

SCHEMBL24465012

C/C=C/C(F)(F)c1ccc(NN2C(=O)C(C)=C(C)C2=O)nc1-c1ccccc1

nearest known ligand 0.40

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
XPO1 O14980 11/20 0.40
NTRK1 P04629 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1592486 0.86 XPO1 (0.48) XPO1NTRK1
SCHEMBL1593000 0.76 XPO1 (0.48) XPO1
SCHEMBL20880320 0.71 XPO1 (0.46) XPO1
SCHEMBL1592489 0.71 XPO1 (0.45) XPO1NTRK1
SCHEMBL30346302 0.71 XPO1 (0.63) XPO1NTRK1
SCHEMBL1592487 0.71 XPO1 (0.43) XPO1NTRK1
SCHEMBL20880362 0.70 XPO1 (0.54) XPO1
SCHEMBL21556185 0.70 XPO1 (0.44) XPO1NTRK1
SCHEMBL8406375 0.70 XPO1 (0.60) XPO1
SCHEMBL24465022 0.68 XPO1 (0.42) XPO1NTRK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3567035-B1 N-SUBSTITUTED 2,5-DIOXO-AZOLINE COMPOUNDS FOR USE IN THE TREATMENT OF CANCER CANBAS CO LTD (JP) 2022-06-01 EP disclosed