Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBK | Q96KB5 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 3/20 | 0.42 |
| ▸ | JAK1 | P23458 | 3/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | CKS1B | P61024 | 1/20 | 0.37 |
| ▸ | SKP1 | P63208 | 1/20 | 0.37 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.36 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24465593 | 0.74 | JAK1 (0.58) | PBKPARP1JAK1JAK2TYK2 | |
| SCHEMBL25519930 | 0.73 | PBK (0.45) | PBKPARP1JAK1JAK2TYK2 | |
| SCHEMBL25528937 | 0.73 | PBK (0.45) | PBKPARP1JAK1JAK2TYK2 | |
| SCHEMBL22941382 | 0.73 | BTK (0.42) | PBKPARP1JAK1JAK2TYK2 | |
| SCHEMBL25519927 | 0.70 | JAK1 (0.48) | PBKPARP1JAK1JAK2TYK2 | |
| SCHEMBL28913117 | 0.70 | JAK1 (0.48) | PBKPARP1JAK1JAK2TYK2 | |
| SCHEMBL21187110 | 0.70 | KDM1A (0.49) | PARP1JAK1JAK2TYK2JAK3 | |
| SCHEMBL628310 | 0.69 | CCRL2 (0.41) | PBKPARP1JAK1JAK2TYK2 | |
| SCHEMBL13240711 | 0.69 | JAK1 (0.52) | PBKJAK1JAK2TYK2JAK3 | |
| SCHEMBL30772750 | 0.69 | JAK1 (0.49) | PBKJAK1JAK2TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4006028-A1 | IRAK4 KINASE INHIBITOR AND PREPARATION METHOD THEREFOR | Zhuhai Yufan Biotechnologies Co., Ltd (CN) | 2022-06-01 | — | — | EP | disclosed |