SCHEMBL24465865

SCHEMBL24465865

Cc1c(F)cc(F)c(N)c1F

nearest known ligand 0.33

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.33
TSHR P16473 2/20 0.33
TP53 P04637 1/20 0.33
CYP3A4 P08684 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
HDAC1 Q13547 2/20 0.32
HDAC6 Q9UBN7 2/20 0.32
CA1 P00915 4/20 0.32
CA2 P00918 4/20 0.32
CA12 O43570 1/20 0.32
CA7 P43166 1/20 0.32
CA13 Q8N1Q1 1/20 0.32
CA9 Q16790 3/20 0.31
DPP4 P27487 1/20 0.30
CA3 P07451 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8102399 0.84 CYP3A4 (0.42) ALDH1A1TSHRTP53CYP3A4TDP1
SCHEMBL28892570 0.83 ALDH1A1 (0.33) ALDH1A1TSHRTP53CYP3A4TDP1
SCHEMBL27120578 0.82 ALDH1A1 (0.36) ALDH1A1TSHRTP53CYP3A4TDP1
SCHEMBL25162229 0.82 ALDH1A1 (0.36) ALDH1A1TSHRTP53CYP3A4TDP1
SCHEMBL5814455 0.82 CA1 (0.38) ALDH1A1TSHRTP53CYP3A4TDP1
SCHEMBL11415512 0.82 HDAC1 (0.37) HDAC1HDAC6CA1CA2CA12
SCHEMBL7073277 0.81 CA1 (0.36) ALDH1A1TSHRTP53CYP3A4TDP1
SCHEMBL18745019 0.80 ALDH1A1 (0.41) ALDH1A1TSHRCYP3A4TDP1HDAC1
Hydrochloric Acid SCHEMBL25243100 0.80 ALDH1A1 (0.38) ALDH1A1TSHRTP53CYP3A4TDP1
SCHEMBL3730086 0.77 CA1 (0.41) HDAC1HDAC6CA1CA2CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4006033-A1 ADENOSINE RECEPTOR ANTAGONIST Xiamen Biotime Biotechnology Co., Ltd. (CN) 2022-06-01 EP disclosed