Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.71 |
| ▸ | RET | P07949 | 6/20 | 0.71 |
| ▸ | SRC | P12931 | 14/20 | 0.59 |
| ▸ | ABL1 | P00519 | 13/20 | 0.59 |
| ▸ | HCK | P08631 | 10/20 | 0.59 |
| ▸ | EGFR | P00533 | 9/20 | 0.59 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.59 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.59 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.59 |
| ▸ | MTOR | P42345 | 7/20 | 0.59 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.59 |
| ▸ | EPHB4 | P54760 | 7/20 | 0.59 |
| ▸ | PRKDC | P78527 | 7/20 | 0.59 |
| ▸ | LCK | P06239 | 2/20 | 0.58 |
| ▸ | EPHA3 | P29320 | 2/20 | 0.58 |
| ▸ | CSK | P41240 | 2/20 | 0.58 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20534669 | 0.83 | RET (1.00) | KDRRETSRCABL1HCK | |
| SCHEMBL24907281 | 0.80 | KDR (0.73) | KDRRETSRCABL1HCK | |
| SCHEMBL24744024 | 0.78 | RET (0.72) | KDRRET | |
| SCHEMBL29904440 | 0.77 | KDR (0.81) | KDRRETSRCABL1HCK | |
| SCHEMBL20534730 | 0.77 | KDR (0.81) | KDRRETSRCABL1HCK | |
| SCHEMBL25858099 | 0.76 | RET (0.86) | KDRRETSRCABL1HCK | |
| SCHEMBL20535281 | 0.76 | KDR (1.00) | KDRRETSRCABL1HCK | |
| SCHEMBL24467463 | 0.76 | KDR (0.70) | KDRRETSRCABL1HCK | |
| SCHEMBL12435987 | 0.75 | SRC (1.00) | KDRSRCABL1HCKEGFR | |
| SCHEMBL24467467 | 0.75 | RET (0.70) | KDRRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3609898-B1 | COMPOUNDS USEFUL AS RET INHIBITORS | CANCER RESEARCH TECH LTD (GB) | 2022-06-01 | — | — | EP | disclosed |