Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 8/20 | 0.41 |
| ▸ | JAK1 | P23458 | 8/20 | 0.41 |
| ▸ | TYK2 | P29597 | 8/20 | 0.41 |
| ▸ | JAK3 | P52333 | 8/20 | 0.41 |
| ▸ | STING1 | Q86WV6 | 5/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19448908 | 0.81 | PTGER4 (0.55) | PTGER4KMT2ANPC1RAB9ARXFP1 | |
| SCHEMBL19436552 | 0.74 | PTGER4 (0.56) | PTGER4KMT2AJAK2JAK1TYK2 | |
| Bromide SCHEMBL29619880 | 0.73 | PTGER4 (0.55) | PTGER4KMT2AJAK2JAK1TYK2 | |
| Bromide SCHEMBL28608182 | 0.73 | PTGER4 (0.55) | PTGER4KMT2AJAK2JAK1TYK2 | |
| SCHEMBL19436565 | 0.71 | PTGER4 (0.55) | PTGER4KMT2AJAK2JAK1TYK2 | |
| SCHEMBL19436572 | 0.70 | STING1 (0.78) | NPC1RAB9ARXFP1STING1TBK1 | |
| SCHEMBL24175826 | 0.70 | STING1 (0.65) | PTGER4KMT2ANPC1RAB9ARXFP1 | |
| SCHEMBL21648038 | 0.70 | NPC1 (0.57) | PTGER4KMT2ANPC1RAB9ARXFP1 | |
| SCHEMBL20075465 | 0.70 | STING1 (0.55) | PTGER4KMT2ANPC1RAB9ARXFP1 | |
| SCHEMBL24175617 | 0.70 | PTGER4 (0.46) | PTGER4KMT2ANPC1RAB9ARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3440076-B1 | HETEROCYCLIC AMIDES USEFUL AS PROTEIN MODULATORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2022-06-01 | — | — | EP | disclosed |