Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 9/20 | 0.40 |
| ▸ | JAK1 | P23458 | 6/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1613189 | 0.90 | NPC1 (0.42) | TYK2JAK1ALDH1A1NPC1RAB9A | |
| SCHEMBL1496794 | 0.90 | NPC1 (0.42) | TYK2JAK1ALDH1A1NPC1RAB9A | |
| SCHEMBL2442988 | 0.81 | JAK1 (0.41) | TYK2JAK1JAK2KITKCNH2 | |
| SCHEMBL5054664 | 0.81 | NPC1 (0.42) | TYK2JAK1JAK2ALDH1A1HPGD | |
| SCHEMBL5054669 | 0.81 | NPC1 (0.42) | TYK2JAK1JAK2ALDH1A1HPGD | |
| SCHEMBL2348121 | 0.79 | NPC1 (0.44) | PKMALDH1A1NPC1RAB9AKMT2A | |
| SCHEMBL2443393 | 0.77 | CXCR2 (0.49) | TYK2JAK1JAK2KITKCNH2 | |
| SCHEMBL2352814 | 0.76 | DHODH (0.45) | MAPTALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL2352820 | 0.76 | DHODH (0.45) | MAPTALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL2446783 | 0.76 | NPC1 (0.39) | TYK2JAK1JAK2KITKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627652-B1 | PYRIDYL BENZOXAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND USE THEREOF | DAE WOONG PHARMA (KR) | 2015-12-16 | — | — | EP | disclosed |
| EP-2627652-A2 | NOVEL PYRIDYL BENZOXAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND USE THEREOF | Daewoong Pharmaceutical Co., Ltd (KR) | 2013-08-21 | — | — | EP | disclosed |
| WO-2012050380-A2 | NOVEL PYRIDYL BENZOXAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND USE THEREOF | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2012-04-19 | — | — | WO | disclosed |
| US-8026235-B1 | Pyridyl benzoxazine derivatives, pharmaceutical composition comprising the same, and use thereof | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2011-09-27 | — | — | US | disclosed |