Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.39 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 4/20 | 0.39 |
| ▸ | TYK2 | P29597 | 4/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1496794 | 1.00 | NPC1 (0.42) | NPC1RAB9ASAE1UBA2KMT2A | |
| SCHEMBL5054664 | 0.91 | NPC1 (0.42) | NPC1RAB9ASAE1UBA2KMT2A | |
| SCHEMBL5054669 | 0.91 | NPC1 (0.42) | NPC1RAB9ASAE1UBA2KMT2A | |
| SCHEMBL2446775 | 0.90 | TYK2 (0.40) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL2348121 | 0.82 | NPC1 (0.44) | NPC1RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL2352820 | 0.78 | DHODH (0.45) | KMT2AMEN1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL2352814 | 0.78 | DHODH (0.45) | KMT2AMEN1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1496803 | 0.77 | CXCR2 (0.50) | NPC1RAB9ASAE1UBA2KMT2A | |
| SCHEMBL1549279 | 0.73 | SMN1; SMN2 (0.45) | NPC1RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL5173867 | 0.73 | SMN1; SMN2 (0.45) | NPC1RAB9AKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2264031-B1 | A NOVEL BENZOXAZINE BENZIMIDAZOLE DERIVATIVE, A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND A USE THEREOF | DAE WOONG PHARMA (KR) | 2015-04-15 | — | — | EP | disclosed |
| US-8362012-B2 | Benzoxazine benzimidazole derivative, a pharmaceutical composition comprising the same, and a use thereof | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2013-01-29 | — | — | US | disclosed |
| US-20110086849-A1 | NOVEL BENZOXAZINE BENZIMIDAZOLE DERIVATIVE, A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND AUSE THEREOF | DAEWOONG PHARMACEUTICALS CO., LTD. (KR) | 2011-04-14 | — | — | US | disclosed |
| EP-2264031-A2 | A NOVEL BENZOXAZINE BENZIMIDAZOLE DERIVATIVE, A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND A USE THEREOF | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2010-12-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110086849-A1 | NOVEL BENZOXAZINE BENZIMIDAZOLE DERIVATIVE, A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND AUSE THEREOF | TRPV1, HRH4, TRPV4 | NPC1 2067/4885RAB9A 3075/4885SAE1 2798/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.