Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.35 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24468294 | 0.80 | CACNA1I (0.36) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL29106431 | 0.80 | CACNA1I (0.36) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL5131540 | 0.74 | KDM4E (0.38) | KCNH2 | |
| SCHEMBL29686184 | 0.71 | CACNA1I (0.33) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL29106427 | 0.71 | CACNA1I (0.33) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL29106411 | 0.71 | CACNA1I (0.33) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL29685834 | 0.71 | CACNA1I (0.33) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL29106407 | 0.71 | CACNA1I (0.33) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL30615171 | 0.71 | CACNA1I (0.33) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL29106408 | 0.71 | CACNA1I (0.33) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022115377-A1 | TRICYCLIC CARBOXAMIDE DERIVATIVES AS PRMT5 INHIBITORS | AMGEN INC. (US) | 2022-06-02 | — | — | WO | disclosed |