Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 3/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.32 |
| ▸ | KRAS | P01116 | 1/20 | 0.31 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29106431 | 1.00 | CACNA1I (0.36) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL24468296 | 0.80 | CACNA1I (0.35) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL469173 | 0.79 | APLNR (0.43) | KCNH2HDAC6 | |
| SCHEMBL24468388 | 0.79 | APLNR (0.43) | KCNH2HDAC6 | |
| SCHEMBL30841912 | 0.79 | APLNR (0.43) | KCNH2HDAC6 | |
| SCHEMBL15481014 | 0.76 | ESR1 (0.35) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL30707764 | 0.76 | L3MBTL1 (0.38) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL24468425 | 0.75 | PDE2A (0.44) | — | |
| SCHEMBL31136292 | 0.75 | PDE2A (0.44) | — | |
| SCHEMBL10236974 | 0.75 | PDE2A (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116783191-A | Tricyclic carboxamide derivatives as PRMT5 inhibitors | 美国安进公司 | 2023-09-19 | — | — | CN | disclosed |
| WO-2022115377-A1 | TRICYCLIC CARBOXAMIDE DERIVATIVES AS PRMT5 INHIBITORS | AMGEN INC. (US) | 2022-06-02 | — | — | WO | disclosed |