Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.47 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGAV | P06756 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24468572 | 0.95 | PRMT5 (0.48) | PRMT5WDR77TRPM8MCHR1SCN9A | |
| SCHEMBL29685440 | 0.95 | PRMT5 (0.48) | PRMT5WDR77TRPM8MCHR1SCN9A | |
| SCHEMBL27181538 | 0.93 | PRMT5 (0.46) | PRMT5WDR77TRPM8MCHR1SCN9A | |
| SCHEMBL24468560 | 0.92 | PRMT5 (0.48) | PRMT5WDR77TRPM8MCHR1SCN9A | |
| SCHEMBL29685302 | 0.92 | PRMT5 (0.48) | PRMT5WDR77TRPM8MCHR1SCN9A | |
| SCHEMBL27181245 | 0.90 | PRMT5 (0.48) | PRMT5WDR77TRPM8MCHR1SCN9A | |
| SCHEMBL24468483 | 0.89 | PRMT5 (0.46) | PRMT5WDR77TRPM8MCHR1SCN9A | |
| SCHEMBL29685297 | 0.89 | PRMT5 (0.46) | PRMT5WDR77TRPM8MCHR1SCN9A | |
| SCHEMBL24468675 | 0.89 | PRMT5 (0.45) | PRMT5WDR77TRPM8MCHR1SCN9A | |
| SCHEMBL29685483 | 0.89 | PRMT5 (0.49) | PRMT5WDR77TRPM8MCHR1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022115377-A1 | TRICYCLIC CARBOXAMIDE DERIVATIVES AS PRMT5 INHIBITORS | AMGEN INC. (US) | 2022-06-02 | — | — | WO | disclosed |