Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.37 |
| ▸ | NAMPT | P43490 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26906023 | 0.93 | KMT2A (0.43) | KMT2AMEN1MMP13GPR119P2RX7 | |
| SCHEMBL3479164 | 0.86 | STAT3 (0.40) | KMT2AMEN1ALDH1A1HPGDNPSR1 | |
| SCHEMBL28310624 | 0.82 | KMT2A (0.43) | KMT2AMEN1MMP13GPR119ALDH1A1 | |
| SCHEMBL15425361 | 0.80 | GRIN2B (0.37) | GPR119NAMPTHPGDNR1H2NR1H3 | |
| SCHEMBL16520138 | 0.79 | KMT2A (0.50) | KMT2AMEN1MMP13GPR119P2RX7 | |
| SCHEMBL27546930 | 0.78 | KMT2A (0.43) | KMT2AMEN1MMP13GPR119ALDH1A1 | |
| SCHEMBL19205366 | 0.77 | MEN1 (0.46) | KMT2AMEN1MMP13GPR119P2RX7 | |
| SCHEMBL3981081 | 0.77 | KMT2A (0.39) | KMT2AMEN1ALDH1A1HPGDNPSR1 | |
| SCHEMBL143673 | 0.77 | KMT2A (0.39) | KMT2AMEN1ALDH1A1HPGDNPSR1 | |
| SCHEMBL23531641 | 0.77 | KMT2A (0.50) | KMT2AMEN1MMP13GPR119P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8722727-B2 | Antifungal agents | Seynix, Inc. (US) | 2014-05-13 | — | — | US | disclosed |
| US-8722727-B2 | Antifungal agents | Seynix, Inc. (US) | 2014-05-13 | — | — | US | disclosed |
| US-8722727-B2 | Antifungal agents | Seynix, Inc. (US) | 2014-05-13 | — | — | US | disclosed |
| EP-2326180-B1 | ANTIFUNGAL AGENTS | MERCK SHARP & DOHME (US) | 2013-10-16 | — | — | EP | disclosed |
| US-8188085-B2 | Antifungal agents | MERCK SHARP & DOHME CORP. (US) | 2012-05-29 | — | — | US | disclosed |
| US-8188085-B2 | Antifungal agents | MERCK SHARP & DOHME CORP. (US) | 2012-05-29 | — | — | US | disclosed |
| US-20110224228-A1 | ANTIFUNGAL AGENTS | MERCK SHARP & DOHME CORP. (US) | 2011-09-15 | — | — | US | disclosed |
| US-20110224228-A1 | ANTIFUNGAL AGENTS | MERCK SHARP & DOHME CORP. (US) | 2011-09-15 | — | — | US | disclosed |
| US-20110224228-A1 | ANTIFUNGAL AGENTS | MERCK SHARP & DOHME CORP. (US) | 2011-09-15 | — | — | US | disclosed |
| US-20100113439-A1 | Antifungal agents | MERCK & CO., INC. (US) | 2010-05-06 | — | — | US | disclosed |
| US-20100113439-A1 | Antifungal agents | MERCK & CO., INC. (US) | 2010-05-06 | — | — | US | disclosed |
| WO-2010019206-A1 | ANTIFUNGAL AGENTS | MERCK SHARP & DOHME CORP. (US) | 2010-02-18 | — | — | WO | disclosed |
| WO-2010019204-A1 | ANTIFUNGAL AGENTS | MERCK SHARP & DOHME CORP. (US) | 2010-02-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224228-A1 | ANTIFUNGAL AGENTS | GMDS, GBA3, UGGT1 | KMT2A 4698/4885MEN1 718/4885MMP13 1519/4885 |
| US-20100113439-A1 | Antifungal agents | GMDS, GBA3, UGGT1 | KMT2A 4676/4885MEN1 736/4885MMP13 1527/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.