Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 20/20 | 0.81 |
| ▸ | MST1R | Q04912 | 3/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | FECH | P22830 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2446196 | 0.89 | MET (0.76) | METMST1R | |
| SCHEMBL2322770 | 0.86 | MET (0.72) | METMST1R | |
| SCHEMBL399926 | 0.84 | MET (1.00) | METMST1RCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2452747 | 0.84 | MET (0.69) | METMST1R | |
| SCHEMBL3952870 | 0.84 | MET (0.69) | METMST1R | |
| SCHEMBL2450541 | 0.82 | MET (0.55) | METMST1RCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2326442 | 0.80 | MET (0.75) | METMST1RCYP3A4CYP2C9FECH | |
| SCHEMBL2326090 | 0.80 | MET (0.75) | METMST1RCYP3A4CYP2C9FECH | |
| SCHEMBL2327639 | 0.80 | MET (0.75) | METMST1RCYP3A4CYP2C9FECH | |
| SCHEMBL398498 | 0.80 | MET (0.80) | METMST1RCYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896421-B1 | BENZOCYCLOHEPTAPYRIDINES AS INHIBITORS OF THE RECEPTOR TYROSINE KINASE MET | MERCK SHARP & DOHME (US) | 2011-09-14 | — | — | EP | claimed |
| US-7550478-B2 | Tyrosine kinase inhibitors | MERCK & CO. INC. (US) | 2009-06-23 | — | — | US | claimed |
| EP-1896421-B1 | BENZOCYCLOHEPTAPYRIDINES AS INHIBITORS OF THE RECEPTOR TYROSINE KINASE MET | MERCK SHARP & DOHME (US) | 2011-09-14 | — | — | EP | disclosed |