Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPFFR1 | Q9GZQ6 | 2/20 | 0.43 |
| ▸ | NPFFR2 | Q9Y5X5 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 2/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2447369 | 1.00 | NPFFR1 (0.43) | NPFFR1NPFFR2ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL21236969 | 0.81 | NPFFR1 (0.40) | NPFFR1NPFFR2ALDH1A1L3MBTL1KIF11 | |
| SCHEMBL15611217 | 0.80 | NPFFR2 (0.65) | NPFFR1NPFFR2ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL16681061 | 0.80 | NPFFR1 (0.42) | NPFFR1NPFFR2ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL16681059 | 0.80 | NPFFR1 (0.42) | NPFFR1NPFFR2ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL15611218 | 0.80 | NPFFR2 (0.65) | NPFFR1NPFFR2ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL16993678 | 0.78 | NPFFR2 (0.71) | NPFFR1NPFFR2KMT2A | |
| SCHEMBL2472098 | 0.78 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1KDM4EHTTNPC1 | |
| SCHEMBL2474936 | 0.78 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1KDM4EHTTNPC1 | |
| SCHEMBL2472101 | 0.78 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1KDM4EHTTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2366704-B1 | Inhibitors of serine proteases | VERTEX PHARMA (US) | 2013-10-23 | — | — | EP | disclosed |
| EP-2631238-A1 | Spirocyclic inhibitors of serine proteases for the treatment of hcv infections | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-08-28 | — | — | EP | disclosed |
| EP-1917269-B1 | INHIBITORS OF SERINE PROTEASES | VERTEX PHARMA (US) | 2011-10-26 | — | — | EP | disclosed |
| EP-2366704-A1 | Inhibitors of serine proteases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-09-21 | — | — | EP | disclosed |
| EP-2364984-A1 | Inhibitors of serine proteases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-09-14 | — | — | EP | disclosed |