Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 17/20 | 0.63 |
| ▸ | TRPV4 | Q9HBA0 | 6/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2442286 | 0.91 | TRPA1 (0.75) | TRPA1TRPV4MAPT | |
| SCHEMBL2445134 | 0.90 | TRPA1 (0.63) | TRPA1TRPV4MAPTSMN1; SMN2 | |
| SCHEMBL2443638 | 0.89 | TRPA1 (0.75) | TRPA1TRPV4MAPT | |
| SCHEMBL2511229 | 0.88 | TRPA1 (0.67) | TRPA1TRPV4MAPTSMN1; SMN2 | |
| SCHEMBL2448645 | 0.87 | TRPA1 (0.70) | TRPA1TRPV4MAPT | |
| SCHEMBL2446718 | 0.85 | TRPA1 (0.68) | TRPA1TRPV4MAPT | |
| SCHEMBL2445395 | 0.85 | TRPA1 (0.63) | TRPA1TRPV4MAPTSMN1; SMN2 | |
| SCHEMBL2444959 | 0.84 | TRPA1 (0.68) | TRPA1TRPV4MAPT | |
| SCHEMBL2439954 | 0.83 | TRPA1 (0.67) | TRPA1TRPV4MAPTSMN1; SMN2 | |
| SCHEMBL2444930 | 0.82 | TRPA1 (0.53) | TRPA1TRPV4MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011114184-A1 | AMIDES OF HETEROCYCLIC COMPOUNDS AS TRPA1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-09-22 | — | — | WO | claimed |
| WO-2011114184-A1 | AMIDES OF HETEROCYCLIC COMPOUNDS AS TRPA1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-09-22 | — | — | WO | disclosed |