Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 9/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 6/20 | 0.35 |
| ▸ | PRKCG | P05129 | 1/20 | 0.31 |
| ▸ | PRKCB | P05771 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | PRKCA | P17252 | 1/20 | 0.31 |
| ▸ | PRKCH | P24723 | 1/20 | 0.31 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.31 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3403132 | 0.81 | CHEK1 (0.35) | CHEK1CHEK2PRKCGPRKCBSRC | |
| SCHEMBL22732907 | 0.81 | CHEK1 (0.35) | CHEK1CHEK2PRKCGPRKCBSRC | |
| Hydrochloric Acid SCHEMBL23698679 | 0.79 | CHEK1 (0.34) | CHEK1CHEK2PRKCGPRKCBSRC | |
| SCHEMBL178427 | 0.74 | — | — | |
| SCHEMBL13799706 | 0.74 | — | — | |
| SCHEMBL16020340 | 0.74 | — | — | |
| SCHEMBL1374772 | 0.71 | — | — | |
| SCHEMBL12312340 | 0.71 | HRH3 (0.43) | CHEK1CHEK2 | |
| SCHEMBL16017560 | 0.69 | EPHX2 (0.36) | CHEK1CHEK2 | |
| SCHEMBL10200598 | 0.69 | EPHX2 (0.36) | CHEK1CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8012961-B2 | Tricyclic antibiotics | ACTELION PHARMACEUTICAL LTD. (CH) | 2011-09-06 | — | — | US | disclosed |