Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 9/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 6/20 | 0.35 |
| ▸ | PRKCG | P05129 | 1/20 | 0.31 |
| ▸ | PRKCB | P05771 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | PRKCA | P17252 | 1/20 | 0.31 |
| ▸ | PRKCH | P24723 | 1/20 | 0.31 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.31 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3403132 | 1.00 | CHEK1 (0.35) | CHEK1CHEK2PRKCGPRKCBSRC | |
| Hydrochloric Acid SCHEMBL23698679 | 0.98 | CHEK1 (0.34) | CHEK1CHEK2PRKCGPRKCBSRC | |
| SCHEMBL23710140 | 0.82 | DRD4 (0.31) | — | |
| SCHEMBL29221316 | 0.81 | AKT1 (0.31) | — | |
| SCHEMBL29221319 | 0.81 | AKT1 (0.31) | — | |
| SCHEMBL29221312 | 0.81 | ALDH1A1 (0.34) | — | |
| SCHEMBL14940865 | 0.81 | PDK1 (0.47) | PRKCGPRKCBPRKCAPRKCHPRKCZ | |
| SCHEMBL29335643 | 0.81 | PDK1 (0.47) | PRKCGPRKCBPRKCAPRKCHPRKCZ | |
| SCHEMBL29221314 | 0.81 | ALDH1A1 (0.34) | — | |
| SCHEMBL9779313 | 0.81 | KDM4E (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3858832-A1 | TRIFLUOROMETHYL-SUBSTITUTED SULFONAMIDE AS BCL-2-SELECTIVE INHIBITOR | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2021-08-04 | — | — | EP | disclosed |
| WO-2020238785-A1 | METHYL- AND TRIFLUOROMETHYL-CONTAINING DISUBSTITUTED SULFONAMIDE SELECTIVE BCL-2 INHIBITOR | 正大天晴药业集团股份有限公司 | 2020-12-03 | — | — | WO | disclosed |