Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL2383704 | 0.94 | KMT2A (0.47) | SMN1; SMN2HPGDMEN1KMT2AALDH1A1 | |
| SCHEMBL2379528 | 0.86 | ROCK2 (0.40) | MEN1KMT2AALDH1A1GAAHSD17B10 | |
| SCHEMBL2420870 | 0.81 | QPCT (0.44) | SMN1; SMN2HPGDMEN1KMT2AALDH1A1 | |
| SCHEMBL2447099 | 0.79 | NPC1 (0.62) | SMN1; SMN2MEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL2379377 | 0.78 | SMN1; SMN2 (0.70) | SMN1; SMN2HPGDMEN1KMT2AALDH1A1 | |
| SCHEMBL2448847 | 0.78 | POLB (0.46) | SMN1; SMN2HPGDMEN1KMT2AALDH1A1 | |
| Acetic Acid SCHEMBL2379861 | 0.76 | KMT2A (0.46) | SMN1; SMN2HPGDMEN1KMT2AALDH1A1 | |
| SCHEMBL2778538 | 0.76 | POLB (0.50) | SMN1; SMN2HPGDMEN1KMT2AALDH1A1 | |
| SCHEMBL2379930 | 0.75 | NPSR1 (0.47) | SMN1; SMN2HPGDMEN1KMT2AALDH1A1 | |
| SCHEMBL2446393 | 0.75 | NPC1 (0.55) | SMN1; SMN2HPGDMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716127-B1 | GUANIDINE COMPOUNDS, AND USE THEREOF AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | ABBVIE DEUTSCHLAND (DE) | 2014-08-06 | — | — | EP | disclosed |
| EP-2380885-A1 | Guanidine compounds and use of same as binding partners for 5-HT5 receptors | Abbott GmbH & Co. KG (DE) | 2011-10-26 | — | — | EP | disclosed |
| EP-2366392-A1 | Guanidine compounds and use of same as binding partners for 5-HT5 receptors | Abbott GmbH & Co. KG (DE) | 2011-09-21 | — | — | EP | disclosed |
| EP-2366697-A1 | Guanidine compounds and use of same as binding partners for 5-HT5 receptors | Abbott GmbH & Co. KG (DE) | 2011-09-21 | — | — | EP | disclosed |