SCHEMBL24478142

SCHEMBL24478142

CNc1cccc(-c2nc(Nc3ccc(S(N)(=O)=O)cc3)ncc2C#N)c1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCNT1 O60563 8/20 0.62
CCNA2 P20248 8/20 0.62
CDK2 P24941 8/20 0.62
CDK9 P50750 8/20 0.62
CCNA1 P78396 5/20 0.62
CDK1 P06493 12/20 0.61
KDR P35968 9/20 0.61
CCNB1 P14635 5/20 0.58
CDK7 P50613 5/20 0.58
CCNH P51946 5/20 0.58
CA12 O43570 1/20 0.47
CA1 P00915 1/20 0.47
CA2 P00918 1/20 0.47
CA4 P22748 1/20 0.47
CA6 P23280 1/20 0.47
CA5A P35218 1/20 0.47
CA7 P43166 1/20 0.47
CA9 Q16790 1/20 0.47
CA13 Q8N1Q1 1/20 0.47
CA14 Q9ULX7 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24478141 0.89 CDK1 (0.62) CCNT1CCNA2CDK2CDK9CCNA1
SCHEMBL24478139 0.87 KDR (0.64) CCNT1CCNA2CDK2CDK9CCNA1
SCHEMBL24478143 0.87 CDK1 (0.62) CCNT1CCNA2CDK2CDK9CCNA1
SCHEMBL24478147 0.86 KDR (0.74) CCNT1CCNA2CDK2CDK9CCNA1
SCHEMBL24478144 0.83 CDK1 (0.58) CCNT1CCNA2CDK2CDK9CCNA1
SCHEMBL24477853 0.80 KDR (0.76) CCNT1CCNA2CDK2CDK9CCNA1
SCHEMBL29314732 0.79 KDR (0.61) CCNT1CCNA2CDK2CDK9CCNA1
SCHEMBL1593001 0.77 CCNT1 (1.00) CCNT1CCNA2CDK2CDK9CCNA1
SCHEMBL6221829 0.77 NPC1 (0.67) CCNT1CCNA2CDK2CDK9CCNA1
SCHEMBL6034601 0.76 KDR (0.68) CCNT1CCNA2CDK2CDK9CCNA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022111621-A1 AMINOHETEROARYL KINASE INHIBITORS ANRUI BIOMEDICAL TECHNOLOGY (GUANGZHOU) CO., LTD. (CN) 2022-06-02 WO disclosed