SCHEMBL2447970

SCHEMBL2447970

COc1ccc(C(O)CC2(C)Cc3cnn(-c4ccc(F)cc4)c3C=C2C)cc1

nearest known ligand 0.59

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NR3C1 P04150 9/20 0.54
GLUL P15104 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1141933 1.00 NR3C1 (0.54) NR3C1GLUL
SCHEMBL1141930 1.00 NR3C1 (0.54) NR3C1GLUL
SCHEMBL1142154 0.93 NR3C1 (0.56) NR3C1GLUL
SCHEMBL1142158 0.93 NR3C1 (0.56) NR3C1GLUL
SCHEMBL1141886 0.89 NR3C1 (0.47) NR3C1
SCHEMBL1141890 0.89 NR3C1 (0.47) NR3C1
SCHEMBL1141888 0.89 NR3C1 (0.47) NR3C1
SCHEMBL1142360 0.88 NR3C1 (0.56) NR3C1
SCHEMBL1142362 0.88 NR3C1 (0.56) NR3C1
SCHEMBL1142292 0.85 NR3C1 (0.49) NR3C1GLUL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1896424-B1 MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kB ACTIVITY AND USE THEREOF BRISTOL MYERS SQUIBB CO (US) 2011-09-21 EP disclosed