Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 19/20 | 0.67 |
| ▸ | TRPV4 | Q9HBA0 | 10/20 | 0.67 |
| ▸ | TRPV3 | Q8NET8 | 4/20 | 0.67 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2445026 | 0.94 | TRPA1 (0.62) | TRPA1TRPV4TRPV3TRPV1MAPT | |
| SCHEMBL10139357 | 0.88 | TRPA1 (0.66) | TRPA1TRPV4TRPV3TRPV1MAPT | |
| SCHEMBL480749 | 0.86 | TRPA1 (0.68) | TRPA1TRPV4TRPV3TRPV1 | |
| SCHEMBL10139318 | 0.86 | TRPA1 (0.72) | TRPA1TRPV4TRPV3MAPT | |
| SCHEMBL612806 | 0.84 | TRPA1 (0.77) | TRPA1TRPV4TRPV3TRPV1 | |
| SCHEMBL2443638 | 0.83 | TRPA1 (0.75) | TRPA1TRPV4MAPT | |
| SCHEMBL2442286 | 0.81 | TRPA1 (0.75) | TRPA1TRPV4MAPT | |
| SCHEMBL474659 | 0.81 | TRPA1 (0.98) | TRPA1TRPV4TRPV3TRPV1 | |
| SCHEMBL474519 | 0.80 | TRPA1 (0.78) | TRPA1TRPV4TRPV3TRPV1 | |
| SCHEMBL474789 | 0.80 | TRPA1 (1.00) | TRPA1TRPV4TRPV3TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011114184-A1 | AMIDES OF HETEROCYCLIC COMPOUNDS AS TRPA1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-09-22 | — | — | WO | disclosed |